期刊文献+

G蛋白信号传导调控因子17在肝癌细胞中的表达及意义 被引量:1

下载PDF
导出
摘要 目的探讨RGS17在原发性肝癌(HCC)发生发展中的作用。方法采用real-time PCR法检测正常肝细胞株THLE-2和肝癌细胞株HepG2、HuH7中RGS17 mRNA表达。结果 HepG2和HuH7细胞中RGS17 mRNA水平明显高于THLE-2细胞,P<0.05。结论 RGS17在HCC的发生发展中可能起促进作用;其具体机制尚需进一步研究。
作者 曹静 王涛
出处 《山东医药》 CAS 2012年第7期43-44,共2页 Shandong Medical Journal
  • 相关文献

参考文献9

  • 1Kawai Y,Arinze IJ.Glucocorticoid regulation of G-protein subunitsin neonatal liver[J].Mol Cell Endocrinol,1993,90(2):203-209.
  • 2McKillop IH,Wu Y,Cahill PA,et al.Altered expression of inhibi-tory guanine nucleotide regulatory proteins(Gi-proteins)in experi-mental hepatocellular carcinoma Cell[J].Physiol,1998,175(3):295-304.
  • 3Ahuja S,Smith SO.Multiple switches in G protein-coupled receptoractivation[J].Trends Pharmacol,2009,30(9):494-502.
  • 4Ross EM.Coordinating speed and amplitude in G-protein signaling[J].Curr Biol,2008,18(17):777-783.
  • 5Kurrasch DM,Huang J,Wilkie TM,et al.Quantitative real-timepolymerase chain reaction measurement of regulators of G-proteinsignaling mRNA levels in mouse tissues[J].Methods Enzymol,2004,(389):3-15.
  • 6Larminie C,Murdoc PK,Walhin JP,et al.Selective expression ofregulators of G-protein signaling(RGS)in the human central nerv-ous system[J].Brain Res Mol Brain Res,2004,122(1):24-34.
  • 7Huang J,Pashkov V,Kurrasch DM,et al.Feeding and fasting con-trols liver expression of a regulator of G protein signaling(Rgs16)inperiportal hepatocytes[J].Comp Hepatol,2006,(5):8.
  • 8Liang Y,Li C,Guzman VM,et al.Identification of a novel alterna-tive splicing variant of RGS5 mRNA in human ocular tissues[J].FEBS J,2005,272(3):791-799.
  • 9Sun Y,Fang R,Li C,et al.Hsa-mir-182 suppresses lung tumori-genesis through down regulation of RGS17 expression in vitro[J].Biochem Biophys Res Commun,2010,396(2):501-507.

同被引文献2

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部