期刊文献+

北枳椇的醒酒和保肝作用研究进展 被引量:5

Research Progress of Hovenia dulcis' Antialcoholism and Liver Protection Effect
下载PDF
导出
摘要 北枳椇(Hovenia dulcis)是治疗酒精中毒和保肝护肝的经典中药之一。近年来的研究表明:北枳椇能够延长醉酒时间并缩短因醉酒而引发的睡眠时间,加速体内酒精代谢,抑制乙醇所致的肌肉松弛,激活酒精代谢过程中重要的酶类,如乙醇脱氢酶(ADH)、乙醛脱氢酶(ALDH)、谷胱甘肽过氧化氢酶(GSH-PX)等。以酒精、四氯化碳(CCl4)、左旋半乳糖胺(D-GaIN)和脂多糖(LPS)等引发的肝损伤模型实验证明,北枳椇具有保肝作用,在一定程度上使得肝功能维持在正常的水平。本文对近年来有关北枳椇解酒保肝作用的研究进展进行了综述。 Hovenia dulcis is one of the classical chinese herbs for antialcoholism and liver protection. Recent researches showed that Ho venia dulcis could prolong ebriety time, shorten sleep time induced by intoxication, accelerate alcohol metabolism, inhibit muscle relaxation caused by ethanol, and activate important enzymes during alcohol metabolism, such as ADH, ALDH, GSHPX. Experiments on models of liver injury caused by alcohol, CC14, D GAIN, LPS and so on showed Hovenia dulcis had the liver protection effect and could maintain the liver function on the normal level to some extent. This paper reviewed recent researches on antialcoholism and liver protection effect of Hove nia dulcis.
出处 《中国食物与营养》 2012年第2期69-72,共4页 Food and Nutrition in China
关键词 北枳椇 解酒醒酒 保肝护肝 药理活性 Hovenia dulcis antialeoholism liver protection pharmacological activity
  • 相关文献

参考文献15

  • 1Sakai K, Yamane T, Saitoh Y, Ikawa C and Nishihata T. Effect of water extracts of crude drugs in decreasing blood alcohol concentrations in rats. Chem. Pharm. Bull. , 1987,35 : 4597-4604.
  • 2陈绍红,钟赣生,李爱里,李少华,吴立坤.枳椇子对酒后血中乙醇质量浓度和肝中乙醇脱氢酶活性的影响[J].中国中药杂志,2006,31(13):1094-1096. 被引量:34
  • 3Okuma Y, Ishikawa H, Ito Y, Hayashi Y, Endo A and Watanabe T. Effect of extracts from Hovenia dulcis Thunb on alcohol concentration in rats and men administered alcohol. Jpn. Nutr. Crop Sci. Bull. , 1995,48:167-172.
  • 4Yoshikawa M, Murakami T, Ueda T, Yoshizumi S, Ni- nomiya K, Murakami N, Matsuda H, Saito M, Fujii W, Tanaka T and Yamahara J. Bioactive constituents of Chinesenatural medicines. III. Absolute stereostructuresof new di- hydroflavonols, hovenitins I, II, and III, isolated from Ho- veniae Semen Seu Fructus, the seed and fruit of Hovenia dul- c/s Thunb. (Rhamnaceae) : Inhibitory effect on a alcohol-in- duced muscular relaxation and hepatoprotective activity. Yakugaku Zasshi, 1997,117 : 108-118.
  • 5Kim K H, Chung YT, Lee J H, Park Y S, Shin M K, Kim H S, Kim D H and Lee H Y. Hepatic detoxification ac- tivity and reduction of serum alcohol concentration of Hovenia dulcis Thunb from Korea and China. Korean J. Medicinal Crop Sci. , 2000,8:225-233.
  • 6Lee H Y, Kim H S, Park Y S. Hovenodulinol, an active compound extracted from Hovenia dulcis Thunb. , a process for preparing the same, and an alcohol decomposing agent or an agent for allevating lingering intoxication containing the same. Korean patent W0/2002/024678, 2002:237-244.
  • 7HongYL, KimMH, AhnC, LeeHY, KimJD. Studies on the biological activities of the extract from Hovenia dulcis Thunb. Inst. Agric. Sci. Kangwon Natl. Uuniv. , 2000,1 : 11.
  • 8XuBJ, DengYQ, JiaXQ, LeeJH, MoEK, KangH J, Sung C K. A rapid screening for alcohol detoxifieation constituents of Hovenia dulcis by microplate reader. Agric. Cherm Biotechnol. , 2003,46 : 105-109.
  • 9Bednarska S, Leroy P, Zagulski M, Bartosz G. Efficacy of antioxidants in the yeast Saccharomyces cerevisiae correlateswith their effects on protein thiols. Biochimie, 2008,90: 1476-1485.
  • 10嵇扬,陆红,杨平.枳椇子酒与枳椇子水提取液解酒毒作用比较研究[J].时珍国医国药,2001,12(6):481-483. 被引量:27

二级参考文献11

共引文献80

同被引文献104

引证文献5

二级引证文献43

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部