静脉炎散治疗下肢深静脉血栓形成的临床观察与药理实验研究

Clinical and experimental studies on Jingmaiyan powders for treating lower limbs with deep venous thrombosis

目的 观察静脉炎散治疗下肢深静脉血栓形成的疗效。方法 临床研究 :2 2 4例下肢深静脉血栓形成患者 ,分 、 、 组。 组 1 0 0例采用静脉炎散 ; 组 64例采用清热燥湿、活血化瘀方剂 ; 组 60例采用复方丹参注射液、蝮蛇抗栓酶、 654- 2针剂等常规疗法。实验研究 :分别进行抗炎、抗凝血、对血瘀证模型血液流变学影响试验。结果 临床结果 : 组的治愈率为 62 % ,明显高于 、 组 48.4%、 46.7% ( P <0 .0 5) ;动物实验结果 :该散剂具有抗炎、抗凝血、溶栓的显著作用 ( P <0 .0 5)。结论 静脉炎散治疗下肢深静脉血栓形成疗效肯定。

Objective To assess the therapeutic efficacy of Jingmaiyan powders (JP) on lower limbs with deep venous thrombosis Methods Clinical study:224 cases with lower limbs with deep venous thrombosis were divided into three groups randomly In group Ⅰ(n=100) JP 2030g was taken orally three times a day, in group Ⅱ(n=64) the actipyretic dampnessdispelling and bloodactivating stasisremoving agents was administered orally once a day, combined with oral entericcoated aspirin 0 3g,and in group Ⅲ(n=60) Fufang Danshen injection 20ml, anisodamine 10mg and hylysantinfarctase 0 5 u were infused intravenously once a day with the 15day therapeutic course and 35 days interval before the next therapeutic course,combined with oral entericcoated aspirin 0.3g . Animal experimental study: the experiments of antiinflammation, anticoagulation and the effect on hemorheology in the bloodstasis models were carried out respectively. Results After 90day therapy,the cure rate in group Ⅰ(62%) was significantly higher than that in group Ⅱ and Ⅲ (48.4% and 46.7%,P<0.05) ; Animal experimental results showed that JP had significant functions in antiinflammation, anticoagulation and thrombolysis. Conclusions JP is an effective preparation in treating lower limbs with deep venous thrombosis.