白桦树皮提取物的降血脂作用研究

On Hypolipidemic Effects of White Birch Bark Extract

目的研究白桦树皮提取物（BH）的降血脂作用．方法分正常组、模型组、BH给药组：高（300mg／kg）、中（200mg／kg）、低（100mg／kg）剂量和阳性对照组：脂必妥（300mg／kg）．预防给药7d，末次给药2h后，腹腔注射75％蛋黄乳液制作小鼠高脂血症模型，造模12h后测定不同剂量的BH对小鼠血脂水平的影响．结果白桦树皮提取物能够显著降低小鼠血清中TC，TG，LDL-C浓度，显著升高HDL-C．结论白桦树皮提取物具有明显的降血脂作用．

Objective To study hypolipidemic effects of white birch bark extract. Method The white birch bark extract （BH） at the dose of 300 mg/kg was given to mice in high-dose group,200 mg/kg in middle-dose group and 100 mg/kg in low-dose group, and Zhinbitieose at the dose of 300 mg/kg in the positive control group orally for 7 days for the prophylaxis of lipidemic disorders. At 2h after the final administration,75% egg yolk emulsion was intraperitoneally given to the mice in all groups except for the normal group to establish the mouse model of hyperlipidemia. Effects of BH at the different doses on lipid levels in blood in mice were measured at 12h after the modeling. Results The white birch bark extract could significantly reduce serum TC, TG and LDL-C contents, and significantly elevate HDL-C level. Conclusion The white birch bark extract can produce significantly hypolipidemic effect on mice.