医院药品不良反应调查分析

INVESTIGATION OF ADVERSE DRUG REACTION OF A HOSPITAL

目的了解药品不良反应(ADR)的基本情况,以提高今后对ADR的重视和上报率。方法采用回顾性研究方法,对某医院收集的57例ADR报告,分别按各年度上报例数、报告来源及不上报ADR的调查原因、药品种类、涉及器官或临床表现等方面进行统计、分析。结果 57例ADR报告中,2007年度ADR上报率最高(占38.6%),医师上报数最多(占79.0%),涉及药品以抗感染药居多(占75.4%),ADR累及的临床表现为皮肤及其附件损害最多(占43.9%)。结论对用药引起的不良反应不容忽视,应采取有效的措施提高报告率。

Objective To understand the basic conditions of a hospital′s adverse drug reactions（ADR） so as to improve the importance and reported rate of ADR in the future. Methods Adopt a retrospective research methods and analyze a hospital collected 57 cases of ADR reports,report the number and resource of cases each year respectively and besides,the don′t reported cases of ADR and its cause,types of drugs,involved organs or clinical manifestations and so on,and then do statistical analysis of them. Results Among 57 cases of ADR reports,the ADR reporting rate in 2007 is the highest（38.6%）,the physicians reported number is the largest（79.0%）,mostly involving drugs to anti-infection（accounting for 75.4%）,ADR accumulated clinical manifestations are involved in the skin and its annexes damage for the most（43.9%）. Conclusion The drug-induced adverse reactions can not be ignored,we should take effective measures to improve the reporting rate.