腹膜后局限性Castleman病误诊嗜铬细胞瘤4例并文献复习

Localized retroperitoneal Castleman's disease resembling pheochromocytoma:a study of 4 cases with literature review

目的探讨腹膜后局限性Castleman病的临床特征及外科治疗方法,结合复习相关文献,以提高腹膜后Castleman病的诊治水平。方法回顾性分析4例术前诊断嗜铬细胞瘤、经手术病理证实为腹膜后Castleman病患者的临床、病理、影像学特点,评价手术治疗效果。结果 4例患者均行手术治疗,切除腹膜后肿瘤,术后病理均为Castleman病。随访12～114个月,均未见肿瘤复发。结论腹膜后Castleman病临床症状不典型,实验室检查通常无异常结果,容易误诊,确诊需靠病理检查,手术切除疗效好。

Objective To investigate the clinical characteristics and surgical treatment of retroperitoneal localized Castleman＇s disease（CD）,review literatures to improve the diagnosis and management of CD.Methods The clinical symptoms,histopathology,CT,MRI findings and efficacy of surgical treatment in 4 patients with CD misdiagnosed as pheochromocytoma before operation were evaluated.Results All patients underwent complete surgical resection.CD was confirmed by histopathology.The duration of follow-up ranged from 12 to 114 months.Patients were all alive without recurrence.Conclusions CD patients have no typical clinical symptoms and have normal laboratory results,the final diagnosis depends on pathologic examination.Surgical resection of the tumor is the best treatment for localized CD.