不同运动训练强度对大鼠胃肠道神经递质的影响

Effect of different-intensity exercise training on neurotransmitters of gastrointestinal motility in rats

目的探讨不同强度运动对大鼠胃肠道神经递质的影响。方法选取成年雄性SD大鼠48只,随机分成3组,即安静对照组、低强度运动组、高强度运动组。各组给予8周不同强度的运动后,测定各组大鼠胃排空率、肠推进率、胃窦组织和十二指肠组织AChE、NOS阳性面积率。结果低强度运动组的胃排空率、肠推进率、胃窦组织和十二指肠组织AChE与安静对照组比较有显著性升高趋势(P<0.05),NOS与安静对照组比较无显著性差异;高强度运动组胃排空率、肠推进率、胃窦组织和十二指肠组织AChE和NOS与安静对照组比较显著性降低(P<0.05),与低强度运动组相比明显下降(P<0.05)。结论低强度运动使大鼠胃排空和肠推进增强,高强度运动对使大鼠胃排空和肠推进有抑制作用,ACh和NO神经递质在其中发挥着重要作用。

Aim To study the effect of different intensity exercise on neurotransmitters of gastrointestinal motility in rats. Methods 48 SD rats were randomly divided into 3 groups： control group, low intensity exercise group,high intensity exercise group. Each group as given different intensity exercises, the concentration of each group gastric emptying rate, intestinal advance rate, gastric and duodenal tissues tissue AchE, NOS positive area ratio were measured. Results The low intensity exercise group rats＇ emptying rate, intestinal advance rate, gastric and duodenal tissue organization by Ache were significantly higher than the control group （P 〈 0. 05 ）, but NOS showed no significant difference ; the highintensity exercise group rats, gastric emptying rate, the rate of promoting intestinal, gastric and duodenal tissues AchE and NOS were significantly lower than the control group and the low intensity exercise group （ P 〈 0. 05 ）. Conclusion Low intensity exercise increases gastric emptying and intestinal propulsion, high intensity exercise inhibits the gastric emptying and intestinal propulsion in rats, ACh and NO neurotransmitters play an important role.