左旋门冬酰胺酶治疗急性淋巴细胞白血病患儿的护理研究

Study on nursing in L-asparaginase(L-asp) treatment of children with acute lymphoblastic leukemia

目的探讨应用左旋门冬酰胺酶(L-Asp)治疗急性淋巴细胞白血病患儿的不良反应及护理对策。方法总结分析18例急性淋巴细胞白血病(ALL)患儿应用L-Asp的不良反应,并针对性落实相应的护理措施。结果不良反应发生率为65%,其中低蛋白血症5例,凝血障碍8例,肝功能异常7例,使用L-Asp前谷丙转氨酶(ALT)平均45 U/L,用后平均128 U/L。血象异常16例,用药前后差异有统计学意义。结论用药前后加强监测及病情观察,及时对症处理,能缓解及减轻患儿用药后的不良反应,促进疾病康复,提高生存质量。

Objective To study the adverse reactions of L-asparaginase （L-asp） in the treatment of children with acute lymphoblastic leukemia （ALL） and the methods of nursing care. Methods The data of adverse reactions Of 18 children with ALL using L-asp were collected and analyzed, and the appropriate care methods were taken according to the different types of adverse reactions. Results The adverse reactions percentage was 65 %, including hypoproteinemia （5 cases）, coagulation dysfunction （8 cases）, abnormal liver function （7 cases）, and peripheral blood abnormality （16 cases）. Among the 7 cases of abnormal liver function, the alanine aminotranderase （ALT） was averagely 45 U/L before using L-asp and 128 U/L after using. There were significant differences before and after using L-asp. Conclusions During using L-asp, the intensive monitor, observation of patients and symptomatic treatment in time can relieve the adverse reactions of ALL children and also accelerate their recovery and promote their life quality.