益智活血汤对多发梗塞性痴呆患者智能及血浆内皮素的影响

Influence of Yizhi Huoxue Decoction (益智活血汤) on Intelligence and Plasma Endothelin of Multiple Infarctional Dementia Patients

采用益智活血汤治疗多发梗塞性痴呆患者53例,同时设脑复康治疗47例为对照,观察治疗前后血浆内皮素(Endothelin,ET)变化。结果:治疗组显效18例,有效29例,无效6例,总有效率为88.68%;对照组显效8例,有效15例,无效24例,总有效率为48.94%,两组比较有显著性差异(P<0.01)。治疗前两组患者ET水平均高于健康对照组(P<0.01),治疗后治疗组患者ET水平明显下降,与治疗前比较有显著性差异(P<0.01),而对照组ET变化无显著差异(P>0.05)

Fifty three patients of multiple infarctional dementia were treated with Yizhi Huoxue Decoction (YHD) and 47 cases treated only with Piracetam were set up as the control group.The change of Endothelin (ET) before and after treatment was observed.Conclusion:In the treatment group,18 cases were markedly effective,29 effective,6 ineffective and the total effective rate was 88.68%;In the control group,it respectively was 8,15,24,48.94%.The difference between the control group and the treatment group was significant (P<0.01).the level of ET in the two groups was higher than the health control group before treatment.And after treatment the level of ET in the treatment group markedly descended,the difference was significant compared with the lever before treatment (P<0.01);while in the control group the difference between before and after treatment was not significant (P>0.05).