摘要
观察棉酚合并 PG0 5对小鼠的抗早孕作用。结果显示 :单用棉酚 75mg/( kg·d) ,3d无抗早孕作用 ,而同样剂量棉酚与 PG0 50 .2 mg/( kg·d) ,合用 2 d可显著增强抗早孕作用 ,使小鼠活胎数进一步减少 ;棉酚 30 μg/ml和 ( - )棉酚 1 5μg/ml对大鼠黄体细胞 3β- HSD活性均有显著抑制作用 ,( + )棉酚 1 5μg/ml和PG0 51 0 μg/ml对此酶活性无影响 ;( - )棉酚 1 5μg/ml还能抑制大鼠颗粒细胞雌二醇的分泌 ,提示棉酚增强 PG0 5抗早孕作用可能是从多环节影响胚胎正常发育。
This study observed the pregnancy interrupting action of gossypol acetic acid(GAA) combined with PG05. The results showed that administration of GAA〔75mg/(kg·d),3d〕 alone couldnt interrupt the pregnancy. And the same dosage of GAA combined with PG05〔0 2mg/(kg·d),2d〕 enhanced significantly the interrupting effect on early pregnancy mice. GAA(30μg/ml) and (-) GAA(15μg/ml) inhibited markedly the activity of 3β HSD of luteal cells in rat, but (+) GAA(15μg/ml) and PG05(10μg/ml) had no inhibitory effect. (-)GAA(15μg/ml) also inhibited significantly basal estradiol production of granulosa in rat. It indicated that the enhanced interrupting effect of PG05 on early pregnancy resulted from further decrease of progesterone production induced by both GAA and PG05.
出处
《西北药学杂志》
CAS
2000年第1期13-15,共3页
Northwest Pharmaceutical Journal
关键词
醋酸棉酚
卡前列甲酯
抗早孕
棉酚
研究
gossypol acetic acid
15 methyl PGF 2α methyl ester
termination of early pregnancy
3β HSD
estradiol