不同浓度谷氨酸钠对蟾蜍离体心脏功能的影响

Effects of Sodium Glutamate on the Function of Isolated Heart in Toad

目的:研究不同浓度谷氨酸钠对蟾蜍离体心肌收缩力和心率的影响。方法:采用蟾蜍离体心脏灌流,给予不同浓度谷氨酸钠的任氏液灌流,使用生物信号采集处理系统记录分析心肌收缩力和心率。结果:10、15mg/mL谷氨酸钠溶液显著增强心肌收缩力(P<0.05),20mg/mL谷氨酸钠溶液使心肌收缩力显著降低(P<0.05);10、15、20mg/mL谷氨酸钠溶液都可使心率显著加快(P<0.05);1mg/mL谷氨酸钠溶液对心肌收缩力和心率的影响均不显著。结论:低浓度谷氨酸钠增强蟾蜍心脏功能,而高浓度谷氨酸钠降低心肌收缩力。

Aim：To study the effects of different concentration sodium glutamate on the contractility and heart rate of isolated heart in toad. Methods ：Isolated heart of toad were perfused with different concentration sodium glutamate. The changes of the contractility and heart rate were recorded and analyzed respectively with biological-medical signal acquisition and processing systems, Results：The solution of 10,15 mg/ml sodium glutamate increased significantly the myocardial contractility （P〈0.05）, and 20 mg/ml sodium glutamate decreased significantly the myocardial contraction （P〈0.05）. The solution of 10,15, 20 mg/ml sodium glutamate in- creased significantly the heart rate （P〈0.01, P〈0.05）. The solution of 1 mg/ml sodium glutamate had no effects on the contractility and the heart rate. Conclusion：The sodium glutamate of lower concentration strengthens the cardiac function, and that higher concentra- tion reduces the myocardial contractility.