摘要
戊型肝炎病毒(hepatitis E virus,HEV)引起的戊型肝炎一直被认为是一种急性自限性感染过程,然而最近发现,器官移植、人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者等免疫力低下的患者感染HEV能够发展为慢性戊型肝炎.有些慢性戊型肝炎病例肝脏快速纤维化而出现肝硬化,并最终导致肝脏衰竭.患者免疫抑制作用减弱,免疫功能恢复有助于体内持续存在的HEV清除.研究发现干扰素和利巴韦林对治疗慢性戊型肝炎有效.
Hepatitis E caused by hepatitis E virus （HEV） has long been considered as an acute self-limiting disease.But in recent years,cases which progress to chronic liver disease mainly in immunocompromised patients have been detected,such as organ transplant recipients and patients with human immunodeficiency virus infection.Studies indicate that chronic HEV hepatitis may result in cirrhosis and end-stage liver disease.Since clearance of the virus depends on the development of specific immunity,lowering the immunosuppressive medication is generally recommended.Ribavirin,interferon-alpha-2a and interferon-alpha-2b were found to be effective in patients with chronic HEV infection.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第2期125-130,共6页
World Chinese Journal of Digestology
关键词
戊型肝炎病毒
慢性戊型肝炎
持续性感染
器官移植
人类免疫缺陷病毒感染
Hepatitis E virus
Chronic hepatitis E
Persistent infection
Organ transplantation
Human immunodeficiency virus infection
