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Cyclin E与结直肠癌的研究进展 被引量：2

Advances in understanding the relationship between cyclin E and human colorectal cancer
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摘要 细胞周期调控紊乱是结直肠癌重要发病机制之一,而Cyclin E是细胞周期最重要的调节因子.研究表明,Cyclin E在结直肠癌的发生、发展中起作用,可能具有评估结直肠癌预后的能力. Cell cycle deregulation is one of important mechanisms leading to human colorectal cancer.It has been revealed that cyclin E is the most important regulatory factor for cell cycle control and plays an important role in the occurrence and development of human colorectal cancer.Detection of cyclin E expression can be used to assess the prognosis of colorectal cancer.
作者 秦光明 黄晓俊 魏义胜
机构地区 兰州大学第二临床医学院消化内科 咸阳市第一人民医院消化内科
出处 《世界华人消化杂志》 CAS 北大核心 2012年第2期131-134,共4页 World Chinese Journal of Digestology
关键词 细胞周期蛋白E 结直肠癌 预后 Cyclin E Colorectal cancer Prognosis
分类号 R735.3 [医药卫生—肿瘤]
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参考文献40

  • 1Koff A,Cross F,Fisher A,Schumacher J,Leguellec K,Philippe M,Roberts JM.Human cyclin E,a new cyclin that interacts with two members of the CDC2gene family.Cell1991;66:1217-1228.
  • 2Hwang HC,Clurman BE.Cyclin E in normal and neoplastic cell cycles.Oncogene2005;24:2776-2786.
  • 3Nanos-Webb A,Jabbour NA,Multani AS,Wingate H,Oumata N,Galons H,Joseph B,Meijer L,Hunt KK,Keyomarsi K.Targeting low molecular weight cyclin E(LMW-E)in breast cancer.Breast Cancer Res Treat2011Jun22.[Epub ahead of print].
  • 4Risch HA.Cyclin E overexpression relates to ovarian cancer histology but not to risk factors.Cancer Epidemiol Biomarkers Prev2008;17:1841;author reply1841-1842.
  • 5Bales ES,Dietrich C,Bandyopadhyay D,Schwahn DJ,Xu W,Didenko V,Leiss P,Conrad N,PereiraSmith O,Orengo I,Medrano EE.High levels of expression of p27KIP1and cyclin E in invasive primary malignant melanomas.J Invest Dermatol1999;113:1039-1046.
  • 6Demetrick DJ,Matsumoto S,Hannon GJ,Okamoto K,Xiong Y,Zhang H,Beach DH.Chromosomal mapping of the genes for the human cell cycle proteins cyclin C(CCNC),cyclin E(CCNE),p21(CDKN1)and KAP(CDKN3).Cytogenet Cell Genet1995;69:190-192.
  • 7Koff A,Giordano A,Desai D,Yamashita K,Harper JW,Elledge S,Nishimoto T,Morgan DO,Franza BR,Roberts JM.Formation and activation of a cyclin E-cdk2complex during the G1phase of the human cell cycle.Science1992;257:1689-1694.
  • 8Nakayama K,Nagahama H,Minamishima YA,Matsumoto M,Nakamichi I,Kitagawa K,Shirane M,Tsunematsu R,Tsukiyama T,Ishida N,Kitagawa M,Nakayama K,Hatakeyama S.Targeted disruption of Skp2results in accumulation of cyclin E and p27(Kip1),polyploidy and centrosome overduplication.EMBO J2000;19:2069-2081.
  • 9Ohtsubo M,Theodoras AM,Schumacher J,Roberts JM,Pagano M.Human cyclin E,a nuclear protein essential for the G1-to-S phase transition.Mol Cell Biol1995;15:2612-2624.
  • 10Porter DC,Zhang N,Danes C,McGahren MJ,Harwell RM,Faruki S,Keyomarsi K.Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms.Mol Cell Biol2001;21:6254-6269.

同被引文献34

  • 1林燕萍,周瑞祥,冯尔宥,黄美雅.健骨颗粒对去卵巢骨质疏松模型鼠钙调节激素的影响[J].中国骨伤,2005,18(1):22-24. 被引量：23
  • 2邹世恩,张绍芬.雌激素对成骨细胞和破骨细胞凋亡的调节机制[J].现代妇产科进展,2006,15(7):547-548. 被引量：18
  • 3Kashima H,Shiozawa T,Miyamot T,et al. Autocrine stim- ulation of IGF1 in estrogen-induced growth of endome- trial carcinoma cells:involvement of the mitogen- activat- ed protein kinase pathway followed by up-regulation of cyclin D1 and cyclin E [J]. Endoer Relat Cancer,2009,16 (1):113-122.
  • 4Prall OW,Sarcevic B,Musgrove EA,et al. Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased Cyelin D1 expression and decreased Cyclin-dependent Kinase inhibitor association with Cyelin E-Cdk2 [J]. J Biol Chem, 1997,272(16): 10882- 10894.
  • 5Maring ED, Tawadros PS, Steer C J, et al. Systematic Review of Candidate Single-nucleotide Polymorphisms as Biomarkers for Re- sponsiveness to Neoadjuvant Chemoradiation for Rectal Cancer [ J]. Anticancer Res,2015,35 (7) :3761-3766.
  • 6Meng X, Li H, Kong L, et al. MRI In rectal cancer: Correlations between MRI features and molecular markers Ki457, HIF-Ic~, and VEGF[ J]. J Magn Reson Imaging,2016.
  • 7Qi F, Yuan Y, Zhi X, et al. Synergistic effects of AKAP95, Cyc- lin DI, Cyclin El , and Cx43 in the development of rectal cancer [J]. Int J Clin Exp Pathol,2015,8(2) :1666-1673.
  • 8Leibold T, Hui VW, Shia J, et al. p27 expression in post-treat- ment rectal cancer: a potential novel approach for predicting resid- ual nodal disease [ J ]. Am J Sm~,2014,208 ( 2 ) : 228-234.
  • 9Suzuki T, Shimada H, Ushigome M, et al. Three-year monitoring of serum p53 antibody during chemotherapy and surgery for stage 1V rectal cancer[J]. Clin J Gastroenterol,2016,9(2) :5568.
  • 10姚新苗,徐禄基,冷涛,张云鹏,方芳.益骨口服液对去势大鼠骨密度与骨生物力学的影响[J].浙江中医药大学学报,2010,34(2):142-143. 被引量：13

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世界华人消化杂志
2012年 第2期

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