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骨膜蛋白在大肠癌的表达和意义 被引量：5

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摘要 大肠癌是我国肿瘤发病率上升最快的肿瘤之一,复发和转移是导致大肠癌患者预后不良和死亡的主要原因,是影响术后生存至关重要的因素,确定术后复发转移的危险因素具有重要意义。骨膜蛋白（periostin）是由鼠成骨细胞分泌的含811个氨基酸残基的蛋白质,由于其在骨膜和牙周韧带的定位表达被称为骨膜蛋白[1]。
作者 司志英 王长征
机构地区 山西省忻州职业技术学院检验教研室
出处 《中国药物与临床》 CAS 2012年第3期311-313,共3页 Chinese Remedies & Clinics
关键词 大肠癌患者 膜蛋白 成骨 术后复发转移 氨基酸残基 预后不良 术后生存 危险因素
分类号 R735.34 [医药卫生—肿瘤]
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参考文献17

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  • 2Bao S,Ouyang G,Bai X,et al.Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.Cancer Cell,2004,5(4):329-339.
  • 3Siriwardena BS,Kudo Y,Ogawa I,et al.Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer.Br J Cancer,2006,95(10):1396-1403.
  • 4Kim CJ,Yoshioka N,Tambe Y,et al.Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells.Int J Cancer,2005,117(1):51-58.
  • 5Yoshioka N,Fuji S,Shimakage M,et al.Suppression of anchorage independent growth of human cancer cell lines by the TRIF52/periostin/OSF-2gene.Exp Cell Res,2002,279(1):91-99.
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同被引文献45

  • 1徐富星.大肠癌研究现状[J].国际消化病杂志,2006,26(6):365-366. 被引量：56
  • 2Watanabe T, Hashimoto T, Sugino T,et al. Production of ILl-beta by ovarian cancer cells induces mesothelial cell betal-integrin expression facilitating p.eritoneal dissemina- tion[J]. J Ovarian Re s, 2012,5 (1) : 1-13.
  • 3Gavalas NG,Liontos M,Trachana SP. Angiogenesis-related pathways in the pathogenesis of ovarian cancer [J]. Int J Mol Sci,2013,14(8), 15885-15909.
  • 4Petrillo M,Scambia G,Ferrandina G. Novel targets for VEGF-independent anti-angiogenic drugs [J]. Expert Opin Invest Drugs, 2012,21 (4) : 451-472.
  • 5Zhu M, Fejzo MS, Anderson L, et al. Periostin promotes o- varian cancer angiogenesis and metastasis[J]. Gyneeol On- col, 2010,119(2) : 337-344.
  • 6Nieman KM, Romero IL,Van Houten B,et al. Adipose tis- sue and adipocytes support tumorigenesis and metastasis [J].Biochim Biophys Acta,2013,1831(10): 1533-1541.
  • 7Wang ZQ,Keita M,Bachvarova M,et all Inhibition of RUNX2 transcriptional activity blocks the proliferation, migration and invasion of epithelial ovarian carcinoma cells[J].PloS One, 2013,8(10): 1-15.
  • 8Keita M,Wang ZQ,Pelletier JF,et al. Global methylation profiling in serous ovarian cancer is indicative for distinct aberrant DNA methylation signatures associated with tu- mor aggressiveness and disease progression[J]. Gyneeol Oncol, 2013,128(2) : 356-363.
  • 9Keita M,Bachvarova M,Morin C,et al. The RUNX1 tran- scription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell proliferation,migration and invasion[J].Cell Cycle, 2013,12(6) : 972-986.
  • 10Planaguma J,Liljestrom M,Alameda F,et al. Matrix met- alloproteinase-2 and matrix metalloproteinase-9 codis- tribute with transcription factors RUNXI/AML1 and ETV5/ERM at the invasive front of endometrial and ovari- an carcinoma[J].Hum Pathol, 2011,42(1):57-67.

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中国药物与临床
2012年 第3期

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