氮酮对骨平巴布膏中葛根素体外透皮吸收的影响

Effect of Azone on in vitro Transdermal Absorption of Puerarin from Guping Cataplasmata

目的:研究氮酮对骨平巴布膏中葛根素体外透皮吸收的影响。方法:采用体外扩散池法研究单用氮酮及氮酮与其他透皮吸收促进剂复合应用时对葛根素透皮吸收的影响。结果:不同质量分数氮酮均可促进葛根素透皮吸收,氮酮与处方中的冰片和挥发油复合应用时透皮效果更好。结论:骨平巴布膏中加入5%的氮酮能够显著增加葛根素的吸收速率和吸收量。

Objective： To study on effect of azone on in vitro transdermal absorption of puerarin from Guping cataplasmata. Method： Transdermal absorption of puerarin was investigated by Franz diffusion pool method when used by azone alone or combination of azone and other penetration enhancers. Result： Transdermal absorption of puerarin could be enhanced by different concentration of azone, especially when azone combined with camphol and volatile oil in this prescription. Conclusion： Added 5% azone in Guping cataplasmata could remarkably increase absorption rate and absorbing capacity of puerarin.