五倍子提取物喷雾膜剂体外释放评价

In vitro Release Evaluation for Spray Film of Extract from Galla Chinensis

目的:建立五倍子提取物喷雾膜剂的体外释放度测定方法,并考察其体外释药特性。方法:以没食子酸为考察指标,采用改良Franz扩散池装置,以半透膜为体外渗透屏障,HPLC测定接收液中没食子酸的含量,计算体外释放度。结果:促渗剂对五倍子提取物喷雾膜剂的释药效果影响不明显,方程拟合以一级动力学方程拟合效果最好。结论:五倍子提取物喷雾膜剂体外释放良好,具有一级动力学特征,不使用促渗剂即可达到较好的释放效果。

Objective： To establish a determination method of in vitro release for spray film of extract from Galla Chinensis, and investigate its in vitro release characteristics. Method： With gallic acid as index, modified Franz diffusion cell was chosen with semi-permeable membrane as in vitro permeability barrier, the content of gallic acid was determined by HPLC and in vitro release of gallic acid was calculated. Result： Affect of penetration enhancers on release effect of this spray film was not obvious, equation of in vitro release model fitted best with Kinetic equation. Conclusion ： This spray film had characteristics of good release and Kinetic equation, it could be achieved a better release effect without penetration enhancers.