生化固本汤防治含顺铂方案化疗所致恶心呕吐反应的临床观察

Clinical Observation on Prevention of Shenghua Guben Decoction on Nausea and Vomiting Induced by Chemotherapy Scheme Contained Cisplain

目的:观察生化固本汤加减防治含顺铂方案化疗所致恶心呕吐反应的临床疗效。方法:86例患者以生化固本汤为治疗组,同时设托烷司琼为对照组,对化疗后恶心呕吐反应的防治效果进行随机交叉对照临床研究。结果:对恶心的控制有效率生化固本汤组为82.6%,托烷司琼组为74.4%,对呕吐的控制有效率生化固本汤组为87.2%,托烷司琼组为88.4%,经分析两组对化疗所致恶心呕吐的防治效果均无统计学意义,但托烷司琼组发生不良反应26例(30.2%),生化固本汤组发生1例(1.2%),两组比较具有统计学意义(P<0.05)。结论:生化固本汤能有效防治含顺铂方案化疗后的恶心呕吐反应,且毒副反应小,值得临床推广。

Objective： To observe the preventive effect of Shenghua Guben decoction on nausea and vomiting caused by chemotherapy scheme involved cisplain. Method： A randomized crossover controlled design was used, 86 patients were randomly allocated to two groups, the Shenghua Guben decoction treatment group and the tropisetron control group. Result： The control rate of nausea was 82.6% and 74. 4% in control group and treatment group, respectively. The control rate of vomiting was 87.2% and 88.4% in control group and treatment group, there was no significant difference between two groups. The rate of adverse reactions was 32.56% in control group, compared with 1.16% in treatment group, there was a significant difference between two groups （P 〈 0. 05）. Conclusion： The Shenghua Guben decoction could effectively prevent and treat nausea and vomiting induced by chemotherapy scheme including cisplain, and the adverse reactions were decreased.