摘要
GALNT2基因属于多肽-N-乙酰氨基半乳糖转移酶家族(简称GalNAc-Ts),其主要功能是参与O-糖基化的第一步反应。目前最新GWAS研究报道GALNT2基因单核苷酸多态性可影响高密度脂蛋白胆固醇及甘油三酯水平,是心血管疾病易感基因之一。因此GALNT2的功能、遗传差异及与心血管疾病的关系将成为今后研究的一个热点。本文较全面的阐述了GALNT2的生物学特性、功能以及GALNT2基因多态性与心血管疾病的关系。
GALNT2 is a key member of polypeptide：N-acetylgalactosaminyltransferase family（GalNAc-Ts）,and recent GWAS based epidemiological study reveal that its polymorphism can interrupt HDLC and TG levels in blood,and is significantly associated with cardiovascular disease.GALNT2 participates in the first step of O-linked glycosylation and is regarded as a cardiovascular disease susceptible gene recently.Therefore,its function and genetic difference as well as the relationship with cardiovascular disease will become a hot research point in the future.This review will focus on the recent advances in research of its biological characteristics,functions,gene polymorphisms and relationship with lipids levels and cardiovascular disease.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2012年第3期278-282,共5页
Chinese Journal of Arteriosclerosis
关键词
GALNT2
基因多态性
高密度脂蛋白
甘油三酯
冠心病
GALNT2
Gene Polymorphism
High Density Lipoprotein Cholesterol
Triglyceride
Coronary Heart Disease
