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药物性肝损伤的临床诊断思路和评估 被引量:7

Clincal diagnostic methods and evaluation of drug-induced liver injury
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摘要 药物引起的肝脏损伤具有致残、延长住院时间、甚至危及生命的风险,作为药物安全性问题的一部分,药物的肝脏毒性正受到医学界、社会公众和药监部门的广泛关注和重视。在美国的肝移植中心,
作者 茅益民
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2012年第3期167-169,共3页 Chinese Journal of Hepatology
基金 国家“十二五”科技重大专项课题基金资助项目(2012ZX09303001-001)
关键词 诊断 药物性肝损伤 方法 Diagnosis Drug-induced liver injury Methods
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参考文献11

  • 1Watkins PB, Seeff LB. Drug-induced liver injury: summary of a single topic clinical research conference. Hepatology, 2006, 43:618- 631.
  • 2Rochon J, Protiva P, Seeff LB, et al. Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug- induced liver injury. Hepatology, 2008, 48:1175-1 183.
  • 3Chalasani N, Fontana RJ, Bonkovsky HL, et al. Causes, clinical features,and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology, 2008, 135: 1924- 1934.
  • 4Bjernsson E, Olsson R. Outcome and prognostic markers in severe drug-induced liver disease. Hepatology, 2005, 42:481-489.
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  • 6Watkins PB, Seligman PJ, Pears JS, et al. Using controlled clinical trials to learn more about acute drug-induced liver injury. Hepatology, 2008, 48: 1680-1689.
  • 7Russmann S, Jetter A, Kullak-Ublick GA. Pharmacogenetics of drug-induced liver injury. Hepatology, 2010, 52: 748-761.
  • 8Lucena MI, Molokhia M, Shen Y, et al. Susceptibility to amoxicillin- clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. Gastroenterology, 2011,141: 338-347.
  • 9Daly AK, Donaldson PT, Bhatnagar P, et al. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet, 2009, 41: 816-819.
  • 10Temple R. Hy's law: predicting serious hepatotoxicity. Pharmacoepidemiol Drug Saf, 2006, 15: 241-243.

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