经NO-cGMP-PDE5通路治疗勃起功能障碍的中药研究进展

Chinese herbal drugs for erectile dysfunction through NO-cGMP-PDE5 signaling pathway

自1990年首次阐明小分子一氧化氮(NO)与阴茎平滑肌松弛之间有紧密联系后,20多年间ED的基础研究取得了很大进展。一氧化氮-环鸟苷酸-磷酸二酯酶5(NO-cGMP-PDE5)通路在ED治疗中的重要作用及相关研究为临床治疗ED提供了坚实的基础。中药治疗ED的历史悠久,目前已阐明部分中药经NO-cGMP-PDE5通路治疗ED的分子生物学机制。本文综述了相关研究。

Great progress has been made in the basic researches on erectile dysfunction （ED） ever since the recognition of the close association of micromolecular nitric oxide （NO） with penile smooth muscle relaxation in 1990. NO-cGMP-PDE5 signaling pathway plays an important role in regulating the relaxation of corpus cavernosum smooth muscle, and its relevant studies have contributed greatly to the clinical treatment of ED. Chinese herbal drugs have long been used in the treatment of ED, and the action mechanisms of some of them clarified through the NO-cGMP-PDE5 signaling pathway. This article presents an overview on the recent advances in the studies of ED treatment with Chinese herbal drugs. Natl J Androl, 2012, 18 （3） ： 260 -265