右归胶囊治疗弱精子症的临床疗效观察研究

Clinical efficacy of Yougui Capsules and Wuziyanzong Pills on oligoasthenospermia

目的:探讨右归胶囊对弱精子症患者精子存活率及活力的影响。方法:2009年4月至2010年5月就诊的不育患者中,将弱精子症患者80例随机分为治疗组和对照组,分别服用右归胶囊和五子衍宗丸,治疗周期为3个月。治疗前后,检测患者精子存活率及其活力。结果:右归胶囊组治疗前精子存活率、a级、a+b级精子百分率分别为31.9%±16.9%,8.2%±3.7%,15.7%±13.9%;治疗后分别为65.7%±13.1%,22.5%±9.1%,47.6%±15.8%,五子衍宗丸组治疗前精子存活率、a级、a+b级精子百分率分别为31.7%±17.0%,7.9%±4.5%,16.9%±13.6%;治疗后分别为38.1%±11.1%,13.2%±6.8%,24.1%±10.9%。两组治疗前与治疗后比较均有显著性差异(P<0.05),治疗后两组间比较有显著性差异(P<0.05)。结论:右归胶囊可提高弱精子症患者的精子存活率及活力,疗效优于五子衍宗丸。

Objective： To investigate the clinical effects of the Chinese traditional medicine Yougui Capsules and Wuziyanzong Pills on sperm viability and motility in patients with oligoasthenospermia. Methods ： A total of 80 infertile men oligoasthenospermia were equally randomized into a trial and a control group, the former treated with Yougui Capsules at 1.68 g tid, while the latter with Wuziyanzong Pills at 6 g bid, both for a course of 12 weeks. The sperm viability and motility of the patients were detected and com- pared before and after medication. Results ： After 12 weeks of medication, the sperm viability and percentages of grade a and grade a ± b sperm were （65.7 ± 13.1 ）, （22.5 ± 9.1 ） and （47.6 ± 15.8） % in the trial group, significantly higher than （ 38.1 ± 11.1 ）, （13.2 ± 6.8） and （24.1 ± 10.9）% in the control （P 〈 0.05）. What＇s more, the above three parameters of the two groups were also significantly higher than those before medication, which were （31.9 ± 6.9 ）, （ 8.2% ± 3.7 ） and （ 15.7 ± 13.9 ） % in the former and （31.7±17.0）, （7.9±4.5） and（16.9±13.6）% in the latter （P〈0.05）. Conclusion： Both Yougui Capsules and Wuziyanong Pills can improve sperm viability and motility in patients with oligoasthenospermia, and the former is even more efficacious than the latter. Natl J Androl, 2012, 18 （3） ： 281 -283