1300cs和5700cs硅油在增殖性糖尿病视网膜病变玻璃体手术中对比研究

Contrast study of 1300cs and 5700cs silicone oil in proliferative diabetic retinopathy vitrectomy

目的对比研究应用1300aS和5700CS两种不同黏滞度硅油在PDR玻璃体手术后，患者的视力恢复情况以及并发症发生率，探讨1300cs硅油短期（〈6个月）填充在PDR玻璃体手术中的使用价值。方法对2007年1月至2011年1月确诊为PDR入院手术治疗且符合研究纳入标准的患者，共240例253只眼。按术中注入1300cs硅油或5700CS硅油将研究对象分为两组，以PDR分期分别进行对比观察。术后随访记录1周、1个月、2个月，后每2个月记录1次直至硅油取出后终止随访。结果术后随访PDR各期两硅油组在术后视力恢复、复发玻璃体积血、并发性白内障、高眼压、角膜变性以及硅油乳化现象对比差异均无统计学意义（均P〉0．05，X2检验，Fisher精确检验）。结论对于不需摘除晶状体的PDR患者短期内填充1300cs和5700cs硅油，其术后视力恢复和并发症发生率无明显差异，出于简化手术操作的考虑，适合使用1300cs硅油。

Objective To compare visual acuity outcomes and complication rates after prolifera- tive diabetic retinopathy vitrectomy using 1300- vs 5700-centistoke silicone oil. Observing the value of using 1300cs silicone oil in short-term （〈6months） in proliferative diabetic retinopathy vitrectomy. Methods The subjects of our hospital from June 2007 to June 2011, which was diagnosed with PDR and met the study inclusion criteria （A total of 240 cases, 253 eyes）, were divided into two groups according to the type of silicone oil injecting during the surgery. One group was 1300-eenti- stoke silicone oil and another was 5700-centistoke silicone oil, the two groups were compared by ev- ery PDR stage. Outcomes were assessed at 1 week, 1 month, 2 months and every 2 months after surgery, the termination of follow-up until the silicone oil removed. Results In any stage of PDR, there was no significant difference between the two groups about the changes in visual acuity, elevat- ed intraocular pressure, vitreous hemorrhage, complicated cataract, corneal opaciftcation and silicone oil emulsification. （All P 〉0.05, x2 test and Fisher exact test）. Conclusions If patients with PDR do not need a long-term silicone oil filling and lens removing in a short-term. Using 1300cs and 5700cs silicone oil are similar in the visual acuity outcomes and complication rates after surgery. In order to simplify the operation, it is a suitable choice of using 1300cs silicone oil.