摘要
目的旨在探究通过纳米骨组织材料治疗骨质疏松的进展,以促进其临床应用。方法由第一作者应用计算机检索PubMed、中国期刊全文数据库(CNKI)1997-05～2011-10相关文献。在标题、摘要、关键词中以"nano,osteoporosis,bone marrow mesenchymal stem cells(BMMSCs),treatment"或"纳米,骨质疏松,骨髓间充质干细胞,治疗"为检索词进行检索。选择文章内容与纳米技术治疗骨质疏松有关者,同一领域文献则选择近期发表在权威杂志文章。结果初检得到127篇文献,根据纳入标准选择36篇文献进行综述。结论纳米技术治疗骨质疏松已经成为骨质疏松治疗中的一项新兴技术。目前通过纳米技术治疗骨质疏松主要通过促进药物吸收,维持药物作用时间,增加药物靶向性,促进干细胞分化的机制来进行骨质疏松的治疗。目前常用的技术包括药物纳米化,纳米微载体,材料表面纳米化,纳米材料修饰干细胞等。但目前纳米技术治疗骨质疏松尚未成熟,仍有许多问题有待解决。
Objective To explore the research progress of nano bone material for the treatment of osteoporosis in order to promote its clinical application.Methods A computer-based online search on the PubMed database and CNKI database was performed to search the relative articles with the
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2012年第2期188-192,共5页
Chinese Journal of Osteoporosis
基金
广东省科技计划项目(2011B031800147)
关键词
纳米
骨质疏松
of ＂nano
osteoporosis
bone marrow mesenchymal stem cells（BMMSCs）
and treatment＂ in English or in Chinese.Literatures related to the nanometer technology for the treatment of osteoporosis were selected.In the same field
the articles published recently in authoritative journals were preferred.Results A total of 127 literatures were primarily selected
and 36 papers were reviewed according to the inclusion criteria.Conclusion Nanotechnology has become a new technology for the treatment of osteoporosis.Currently
the mechanisms of nanometer technology for the treatment of osteoporosis mainly focus on promoting the drug absorption
maintaining drug functional time
increasing drug targeting
and promoting the differentiation of stem cells.The most common technology includes nano-drug
drug nanocapsule system carrier
nano surface materials
and nano-modified stem cells.But the application of nanotechnology for the treatment of osteoporosis is not yet mature
and there still are many issues to be resolved. Key words： Nanometer
Osteoporosis
