农村居民脑卒中危险因素及其交互作用研究

Risk factors of stroke and their interactions in rural residents

目的探讨农村居民脑卒中的危险因素及其交互作用对脑卒中发病的影响。方法采用以人群为基础的病例-对照研究方法,随机选择患者232人,健康对照232人进行调查。应用检验和Logistic回归分析脑卒中危险因素,应用相加效应模型分析脑卒中危险因素与家族史的交互作用。结果长时间精神压抑、月经不规律和家族史是脑卒中的重要危险因素,其OR值分别为1.943、3.698和2.473;长时间精神压抑、月经不规律与家族史在脑卒中发病中存在交互作用,交互作用指数分别为1.656和6.034;交互作用归因危险比分别29.2%和79.6%;交互作用相对超额危险度分别为1.118和2.504。结论长时间精神压抑、月经不规律和家族史是脑卒中的重要危险因素,而且长时间精神压抑和月经不规律与家族史之间存在正交互作用。

[ Objective ] To explore the risk factors of stroke and their interactions in rural residents. [ Methods ] With the method of population-based case-control study, we randomly selected 232 cases and 232 controls. Using testing and Logistic regression to analyze the risk factors of stroke, and to analyze the interactions with additive ef- fects model. [ Results ] Long-time psychological repression, irregular menstruation and family history of stroke are the important risk factors of stroke, OR is 1.943, 3.698 and 2.473, respectively. Long-time psychological repression and irregular menstruation have a positive interaction with family history of stroke, S is 1.656 and 6.034, API is 29.2% and 79.6%, RERI is 1.l 18 and 6.034, respectively. [ Conclusion ] Long-time psychological repression, ir- regular menstruation and family history of stroke are the important risk factors of stroke, long-time psychological re- pression and irregular menstruation have an positive interaction with family history.