糖调节受损患者氧化应激损伤和炎症标志物的临床分析

Clinical analysis of oxidative stress damage and inflammatory markers in patients with impaired glucose regulation

目的探讨IGR患者氧化应激和炎症标志物的水平及其与胰岛功能、糖脂代谢指标的相关性。方法选取门诊IGR患者、DM患者和正常人(NGT)进行相关数据统计分析。结果 NGT组、IGR组和DM组SOD依次降低,MDA、C-RP、IL-6、TNF-α依次升高。SOD与HOMA-IR呈中度负相关,与HOMA-β、△I30/△G30、△I120/△G120呈中度正相关;MDA与C-RP、IL-6、TNF-α与HOMA-IR呈中度正相关,与HOMA-β、△I30/△G30、△I120/△G120呈中度负相关。影响SOD、MDA、C-RP、IL-6、TNF-α的主要因素有WHR、HbA1c、TG。结论在IGR阶段,机体已经受到明显的氧化应激损伤,并发生炎症反应的激活。

Objective To investigate the level of oxidative stress damage and inflammatory markers in patients with IGR, and to analyze the correlation of the markers with islet function, glucose and lipid metabolism. Methods Outpatient cases were selected from Traditional Chinese Medicine Department of Peking University First Hospital, who had received a blood test of glucose, lipid and insulin. The 80 cases meeting the diagnostic criteria of IGR and the 48 cases meeting the diagnostic criteria of type 2 diabetes mellitus were the study subjects, and the other 40 people with normal glucose tolerance were the healthy control group. ReLated data of three groups were analyzed. Results In NGT group, IGR group and T2DM group, antioxidants SOD decreased when oxidative stress end products MDA and inflammatory markers C-RP, IL-6 and TNF-a increased. SOD had a moderately negative correlation with HOMA-IR, and had a moderately positive correlation with HOMA-β,△130 /△ Ga0 and △ I120 /△G120. MDA, C-RP, IL-6 and TNF-α showed a moderately positive correlation with HOMA-IR, and a moderately negative correlation with HOMA-β, △ Ia0 / △ G30 and △ I120 / △ G120. WHR, HbA1 c and TG were main influencing factors of SOD, MDA, C-RP, IL-6 and TNF-α. Conclusion In IGR stage, patients have been subjected to oxidative stress injury which activates the inflammatory response. Oxidative stress and inflammation form a vicious cycle, which to a certain extent increases insulin resistance and impairs the function of pancreatic islet 13 cells. Abdominal obesity, long-term high blood glucose and hyperlipidemia are the main factors of oxidative stress and inflammation.