米托坦的合成

Synthesis of Mitotane

2-氯苯甲醛和氯仿在氢氧化钾甲醇溶液和DMF中反应得到2,2,2-三氯-1-(2-氯苯基)乙醇,再经铝汞齐还原、与氯苯在浓硫酸作用下反应制得抗肿瘤药米托坦,总收率约27%。

Mitotane, an antineoplastic agent, was synthesized from 2-chlorobenzaldehyde by reaction with chloroform in KOH/CH3OH and DMF to give 2,2,2-trichloro-1-（2-chlorophenyl）ethanol, which was subjected to reduction followed by reaction with chlorobenzene in the present of sulfuric acid with an overall yield of about 27 %.