毛萼乙素纳米混悬剂.Ⅱ.对小鼠肝癌H22移植瘤的生长抑制作用

Eriocalyxin B Nanosuspension.Ⅱ.Inhibitory Effects on H22 Hepatoma-bearing Mice

采用小鼠肝癌H22移植性肿瘤模型,考察不同给药途径和剂量下,毛萼乙素纳米混悬剂的抗肿瘤作用及毒性。在适宜的给药剂量下,毛萼乙素纳米混悬剂经静脉注射、腹腔注射和灌胃3种途径给药均可抑制小鼠肝癌H22移植瘤的生长,并呈现明确的量效关系,但其毒性也随着剂量的增加而明显增大。在10 mg/kg的剂量下,腹腔注射的抑瘤作用优于静脉注射;但该途径给药产生的毒性也比静脉注射大。灌胃给药的抑瘤作用最弱,且高剂量时会产生严重的胃肠道不良反应。

The antitumor effect and toxicity of eriocalyxin B nanosuspension on H22 hepatoma-bearing mice were investigated under different administration routes and dosages. The inhibition effect could be achieved by all three routes （iv, ip and ig administration） with the appropriate dose, and a clear dose-effect relationship was observed. Meanwhile, the toxicity was significantly increased with the increasing of dose. The inhibition of ip administration was higher than that of iv at the dose of 10 mg/kg, and the toxicity of ip route was higher. The antitumor effect of ig administration was the weakest, and the serious gastrointestinal adverse reactions were observed in the high-dose group.