水朝阳旋覆花化学成分的研究(英文)

Chemical Constituents from Inula helianthus-aquatica

从水朝阳旋覆花(Inula helianthus-aquatica)地上部分分离得到24个化合物,经波谱数据分析分别鉴定为aromaticin(1),8-epi-helenalin(2),bigelovin(3),2,3-dihydroaromaticin(4),carpesiolin(5),ergolide(6),inuchinenolide C(7),6α-acetoxy-isoinuviscolide(8),8-epi-inuviscolide(9),inuchinenolide B(10),tomentosin(11),11α,13-dihydrotomentosin(12),inuchinenolide A(13),4H-tomentosin(14),11β,13-dihydro-4H-tomentosin(15),11-epi-sundiversifolide(16),sundiversifolide(17),8,9,10-三羟基百里香酚(18),10-羟基-8,9-双氧亚异丙基百里香酚(19),8,10-二羟基-9-异丁酰百里香酚(20),8-羟基-9,10-二异丁酰百里香酚(21),8-羟基-9-异丁酰-10-(2-甲基丁酰)百里香酚(22),8,9-环氧-9,10-二异丁酰百里香酚(23)和8,9-环氧-3-异丁酰-10-(2-甲基丁酰)百里香酚(24)。除了化合物1～6外,其他化合物均为首次从该植物中分离得到。

Twenty-four compounds were isolated from the aerial parts of Inula helianthus-aquatica. On the basis of spec- tral data, their structures were identified as aromaticin （ 1 ）, 8-epi-helenalin （2）, bigelovin （3）, 2,3-dihydroaromaticin （4） ,carpesiolin （5）, ergolide （ 6 ）, inuchinenolide C （ 7 ）, 6ct-acetoxy-isoinuviscolide （ 8 ）, 8-epi-inuviscolide （ 9 ）, inuchinenolide B （ 10 ）, tomentosin （ 11 ）, 11 ct, 13-dihydrotomentosin （ 12 ）, inuchinenolide A （ 13 ）, 4H-tomentosin （14）, 11β, 13-dihydre-4H-tomentosin （ 15）, 11-epi-sundiversifolide （ 16）, sundiversifolide （ 17）, 8,9,10-trihydroxythy- tool （ 18 ）, 10-hydroxy-8,9-dioxyisopropylidenethymol （ 19 ）, 8,10-dihydroxy-9-isobutyryloxythymol （ 20 ）, 8-hydroxy-9, 10-diisobutyryloxythymol （ 21 ）, 8-hydroxy-9-isobutyryloxy-10-（2-methylbutanoyl） thymol （ 22 ）, 8,9-epoxy-3, 10-di- isobutyryloxythymol （23）, and 8,9-epoxy-3-isobutyryloxy-10- （2-methylbutanoyl） thymol （ 24 ）. All the compounds ex- cept 1-6 were isolated from this plant for the first time.