放疗并发呼吸道感染患者血清炎性因子水平变化研究

Research on change of levels of serum inflammatory factors in patients with concurrent respiratory tract infections after radiotherapy

目的探讨放疗并发呼吸道感染患者血清炎性因子水平的变化规律。方法选取2008年1月-2011年6月在医院进行放疗并发呼吸道感染的28例患者为研究对象,将其设为观察组,同时选取同期进行放疗无感染并发症存在的28例患者为对照组,将两组患者的血清CRP、IL-2、IL-6、IL-8及TNF-α水平进行统计及比较。结果观察组的血清CRP(15.58±2.41)mg/L、IL-6(405.41±31.02)pg/ml、IL-8(193.65±20.26)ng/ml及TNF-α(256.41±23.16)ng/ml水平高于对照组,而IL-2(1.14±0.39)ng/ml水平低于对照组,差异均有统计学意义(均P<0.05)。结论放疗并发呼吸道感染患者血清炎性因子水平波动幅度较大,可以反映感染的存在。

OBJECTIVE To investigate the changes in the levels of serum inflammatory factors of in patients complicated by respiratory tract infections after concurrent radiotherapy.METHODS A total of 28 patients with concurrent respiratory tract infection who received radiotherapy from Jan.2008 to Jun.2011 were enrolled in the observation group.Another 28 patients with radiotherapy but with no complication at the same time period were defined as control group.Serum CRP,IL-2,IL-6,IL-8 and TNF-α levels of the two groups of patients were compared statistically.RESULTS The serum CRP（（15.58 ± 2.41） mg/L）,IL-6（（405.41±31.02）pg/ml）,IL-8（（193.65±20.26）ng/ml） and TNF-α（（256.41±23.16）ng/ml） levels of the observation group were higher than those of the control group,but IL-2（（1.14±0.39）ng/ml） level of the observation group was lower than that of the control group,the differences were statistically significant（P0.05）.CONCLUSION The fluctuations of levels of serum inflammatory factors in patients with radiotherapy concurrent respiratory tract infection is obvious,which may reflect the presence of infection.