中心静脉导管感染的病原菌分布及耐药性分析

Venous catheter bacterial infections and analysis of drug resistance

目的研究中心静脉导管引起感染的病原菌分布及其耐药性,为临床治疗提供依据。方法回顾性分析2008年8月-2010年8月中心静脉导管送检标本培养出的病原菌分布及耐药性。结果送检的532份样本中,中心静脉导管培养阳性83份,阳性率为15.6%;检出病原菌中革兰阳性球菌48株占57.8%,革兰阴性杆菌24株占28.9%,真菌11株占13.3%;对革兰阳性球菌敏感性较高的药物有万古霉素、替考拉宁,敏感率分别为100.0%、92.31%～100.00%;对革兰阴性杆菌中鲍氏不动杆菌的敏感性较高的药物有头孢哌酮/舒巴坦,敏感率为58.3%。结论革兰阳性球菌是静脉导管感染最常见的病原菌,且耐药严重,应加强细菌检测,有效控制静脉导管感染。

OBJECTIVE To study the pathogens causing venous catheter-associated infection and the drug resistance,so as to provide evidence for clinical management.METHODS From Aug.2008 to Aug.2010,the pathogens cultured from central venous catheters and the drug resistance were analyzed retrospectively.RESULTS Of all 532 samples submitted,83 samples were cultured positive for bacterial strains,with the positive rate of 15.6%;among the pathogens cultured,gram-positive cocci were 48 strains（57.8%）,gram-negative bacilli were 24 strains（28.9%）,and fungi were 11 strains（13.3%）.Gram-positive cocci were relatively susceptible to vancomycin and teicoplanin.Among the gram-negative bacilli,Acinetobacter baumannii had high susceptibility to cefoperazone/sulbactam.CONCLUSION gram-positive cocci are the most common pathogens causing venous catheter-associated infections and have serious drug resistance.Bacterial detection should be strengthened in order to control venous catheter-associated infections effectively.