术前口服伊托必利在胶囊内镜检查中的作用分析

Effects of itopride prior to capsule endoscopy

目的探讨胶囊内镜检查前患者口服伊托必利的临床价值。方法40例疑似小肠疾病患者采用随机数字表法均分入观察组和对照组，观察组术前1d口服盐酸伊托必利片，检查当日两组肠道准备相同，比较两组小肠清洁度、胶囊内镜胃转运和小肠转运时间以及病变检出率的差异。结果观察组小肠清洁度优良率为80％（16／20），明显优于对照组的45％（9／20）（P〈0．05）。观察组平均胃转运时间为31min，明显短于对照组的56min（P〈0．05）；平均小肠转运时间为251min，明显短于对照组的327min（P〈0．05）。观察组小肠病变检出率为60％（12／20），明显高于对照组的40％（8／20）（P〈0．05）。结论胶囊内镜检查前患者口服伊托必利具有较好的临床价值。

Objective To evaluate the clinical effects of oral administration of itopride prior to capsule endoscopy on bowel preparation. Methods A total of 40 patients who underwent capsule endoscopy from April, 2010 to April, 2011 were randomly assigned to the medication group and the control group （n = 20 per group）. The medication group took itopride on the day before capsule endoscopy. The two groups un- derwent the same procedure for bowel preparation. Clearance, gastric transit and intestinal transit of capsule endoscope, lesion detection rates were compared between the two groups. Results Bowel preparation of high quality in the medication group was 80% （16/20）, significantly higher than that （45%, 9/20） in the control group （P 〈 O. 05 ）. The mean gastric and intestinal transit times in the medication group were 31 min and 251 min, respectively, significantly shorter than those in the control group （P 〈 0. 05）. While lesion de- tection rate in the medication group （60%, 12/20） was significantly higher than that of the control （40%, 8/20） （P 〈 0. 05）. Conclusion Oral itopride is of better clinical value for capsule endoscopy preparation.