解脲支原体感染与早产儿血液系统、炎症反应相关性研究

Study on the correlation between Ureaplasma urealyticum infection and blood system and inflammatory reaction of premature infants

目的:探讨解脲支原体感染与早产儿血液系统、炎症反应、肺部损伤的关系。方法:对2010年1～12月该院收治的早产儿采集痰液进行解脲支原体检测,检出49例阳性患儿(阳性组),另外选择80例阴性患儿(对照组),比较两组血常规、IL-6、IL-8、胸片、胎膜早破率。结果:阳性组白细胞总数(19.12±1.52)×109/L、IL-6(47.19±1.50)pg/ml、IL-8(18.81±1.21)pg/ml、胸片异常率为45.80%、胎膜早破率为53.60%,均高于对照组(P<0.05)。结论:解脲支原体感染与早产儿血液系统、炎症反应、肺部损伤有关,早产儿应尽早行UU-DNA检测,并结合血常规、IL-6、IL-8、胸片结果综合分析,予早期诊断和治疗。

Objective： To explore the relationship between Ureaplasma urealyticum infection and blood system, inflammatory reaction, and pulmonary injury of premature infants. Methods： The sputum samples of the premature infants who were treated in the hospital from January to December in 2010 were collected for Ureaplasma urealyticum detection, 49 positive premature infants were detected （positive group）, 80 negative premature infants were selected as control group, the results of blood routine examination, the levels of interleukin-6 and interleukin- 8, the results of chest film examination, and the incidences of premature rupture of membrane （PROM） in the two groups were compared. Results： In positive group, the total amount of white blood cells was （ 19. 12 ±1.52） × 109/L, the level of interleukin - 6 was （47. 19 ± 1.50） pg/ml, the level of interleukin - 8 was （ 18.81± 1.21 ） pg/ml, the incidenee of chest film abnormality was 45.80%, the incidence of PROM was 53.60%, all the indexes abovementioned were significantly higher than those in control group （ P 〈 0. 05 ） . Conclusion： Ureaplasma urealy＇ticum infection is related to blood system, inflammatory reaction, and pulmonary injury of premature infants, Ureaplasma urealyticum DNA detection should be performed early among the premature infants, then the results were analyzed combined with blood routine examination, interleukin-6 and intedeukin-8 levels, and chest film examination, so early diagnosis and treatment are eonducted.