多囊卵巢综合征患者超排卵中卵泡发育迟缓相关指标分析

Analysis on related indexes of follicular developmental retardation during controlled ovarian hyperstimulation among the patients with polycystic ovary syndrome

目的:探讨多囊卵巢综合征(polycystic ovarian syndrome,PCOS)不孕症患者体外受精-胚胎移植(IVF-ET)或单精子卵胞浆内注射(ICSI)超排卵(COH)长方案中卵泡发育迟缓的原因。方法:回顾性分析2009年12月～2010年12月多囊卵巢综合征不孕症患者超排卵40个周期,卵泡正常发育组(A组)19个周期,卵泡发育迟缓组(B组)21个周期作为对照。结果:年龄、不孕年限,基础生殖激素水平在两组间无统计学差异(P>0.05)。与B组比较,A组促性腺素(Gn)起始剂量低于B组(P<0.05)。A组促排天数、Gn总量明显高于B组(P<0.05)。A组受精率、卵裂率、OHSS发生率、优质胚胎数及临床妊娠率均低于B组(P<0.05)。结论:Gn起始剂量低可能是造成PCOS患者超排卵卵泡发育迟缓的一个重要因素。

To explore the causes of follicular developmental retardation during long protocol controlled ovarian hypers- timulation （COH） of in vitro fertilization and embryo transfer （IVFET） or intracytoplasmic sperm injection （ICSI） among the infertile patients with polycystic ovary syndrome （PCOS） . Methods： Forty COH cycles of the infertile patients with PCOS from December 2009 to December 2010 were analyzed retrospectively, then they were divided into follicular normal development group （group A, 19 cycles） and follicular developmental retardation group （group B, 21 cycles） . Results： There was no significant difference in age, the duration of infertility, basic reproductive hormones levels between the two groups （P 〈 O. 05 ） . The start dose of gonadotropin in group A was lower than that in group B （ P 〈 0.05 ） . The duration of ovulation stimulation and the total dose of gonadotropin in group A were significantly higher than those in group B （P 〈 0.05 ） . The fertilization rate, cleavage rate, the incidence of ovarian hyperstimulation syndrome （OHSS）, the number of high quality embryo, and clinical pregnancy rate in group A were significantly lower than those in group B （P 〈 0. 05 ） . Conclusion： The low start dose of gonadotropin may be one of the important factors inducing follicular developmental retardation during COH among the patients with PCOS.