布鲁氏菌胞内寄生的研究进展

Research Advance on Brucella Parasitism Mechanism

布鲁氏菌是一种能够在哺乳动物巨噬细胞内生存和增殖的兼性厌氧菌。近年来,布鲁氏菌的研究主要集中在参与细胞内寄生过程中的毒力因子及其对宿主细胞的影响。主要论述布鲁氏菌如何逃避巨噬细胞的防御及其在细胞内寄生状况。

Brucella is a facultative anaerobic intracellular bacterium, which can survive and replicate inside mammalian host macrophages, and causes animal and human brucellosis. In recent years, studies focus on virulence factors and their functions involved in various stages of Brucella intracellular life cycle. How this pathogen escaped macrophage defense mechanisms and generated organelle permissive for replication was studied.