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G蛋白耦联受体30在激素相关性肿瘤中的作用

Function and advance of GPR30 in hormone-related neoplasms
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摘要 G蛋白耦联受体30（GPR30）是一种新鉴定的雌激素功能性膜受体，介导雌激素的快速非基因组效应，从而广泛参与机体的病理生理调控，尤其在激素相关性恶性肿瘤中的的发生发展过程中起重要作用。 G protein-coupled receptor 30 （ GPR30）, a sort of novel functional estrogen transmembrane receptor, extensively participate in the pathological and physiological regulation by mediating the rapid nongenomic effects of the estrogen, which plays an important role in the occurrence and development of the hormone-related malignant neoplasms.
作者 蔡玲玉 贺银燕 席晓薇
机构地区 上海交通大学附属第一人民医院妇产科
出处 《国际肿瘤学杂志》 CAS 2012年第3期166-169,共4页 Journal of International Oncology
基金 基金项目：国家自然科学基金资助项目（81001154）
关键词 雌激素 乳腺肿瘤 子宫内膜肿瘤 卵巢肿瘤 G蛋白偶联受体30 Estrogens Breast neoplasms Endometrial neoplasms Ovarian neoplasms GPR30
分类号 R730.2 [医药卫生—肿瘤]
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参考文献23

  • 1Prossnitz ER, Arterburn JB, Smith HO, et al. Estrogen signalingthrough the transmembrane G protein-coupled receptor GPR30. Annu Rev Physiol, 2008, 70: 165-190.
  • 2Langer G, Bader B, Meoli L, et al. A critical review of fundamental controversies in the field of GPR30 research. Steroids, 2010, 75 (8-9) : 603-610.
  • 3Otto C, Rohde-Schuh B, Schwarz G, et al. G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol. Endocrinology, 2008, 149(10) :4846-4856.
  • 4Matsuda K, Sakamoto H, Mori H, et al. Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation. Neurosci Lett, 2008, 441 ( 1 ) : 94-99.
  • 5Prossnitz ER, Maggiolini M. Mechanisms of estrogen signaling and gene regulation viaGPR30. Mol Cell Endocrinol, 2009, 308 ( 1-2 ) : 32-38.
  • 6Ignatov A, Ignatov T, Roessner A, et al. Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells. Breast Cancer Res Treat, 2010, 123( 1 ) :87-96.
  • 7Chan QK, Lain HM, Ng CF, et al, Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erkl/2, c-Jun/c-fos-dependent upregnlation of p21, and induction of G ( 2 ) cell-cycle arrest. Cell Death Differ, 2010, 17(9) : 1511-1523.
  • 8Sun J, Chu Z, Moenter SM. Diumal in vivo and rapid in vitro effects of estradiol on voltage-gated calcium channels in gonadotropin-releasing hormone neurons. J Neurosci, 2010, 30( 11 ) : 3912-3923.
  • 9Lin BC, Suzawa M, Blind RD, et al, Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res, 2009, 69 ( 13 ) : 5415- 5423.
  • 10Li Y, Birnbaumer L, Teng CT. Regulation of ERRalpha gene expression by estrogen receptor agonists and Antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by G protein-coupled receptor GPR30/GPER-1. Mol Endocrinol, 2010, 24(5) : 969-980.
国际肿瘤学杂志
2012年 第3期

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