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BRAF^V600E基因突变与甲状腺乳头状癌

BRAF^V600E gene mutation in papillary thyroid cancer
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摘要 BRAF^V600E基因突变是甲状腺乳头状癌中最常见的遗传学事件，是浸润性肿瘤临床表型和预后不佳的指标。BRAF^V600E因突变检测对甲状腺恶性结节的术前鉴别诊断及指导甲状腺癌的手术切除范围、判断患者预后、指导术后后继治疗均有重要的指导意义。 The BRAF^V600E mutation in papillary thyroid carcinoma is the most common genetic event, which is an invasive tumor clinical phenotype and a poor prognosis indicator. The BRAF^V600E mutation detection has an important guiding significance for the differential diagnosis of malignant thyroid nodules on preoperative, guiding the surgical resection range of thyroid cancer, judging the patient＇s prognosis and guiding the subsequent treatment of postoperative.
作者 焦小平 王圣应
机构地区 蚌埠医学院第一附属医院肿瘤外一科
出处 《国际肿瘤学杂志》 CAS 2012年第3期206-208,共3页 Journal of International Oncology
关键词 甲状腺肿瘤 腺癌 乳头状 点突变 Thyroid neoplasms Adenocarcinoma, papillary Point mutation
分类号 R736.1 [医药卫生—肿瘤]
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参考文献24

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国际肿瘤学杂志
2012年 第3期

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