表皮生长因子受体在食管癌放疗中的应用

Application of epidermal growth factor receptor for radiotherapy of esophageal cancer

表皮生长因子受体（EGFR）在食管癌中高表达或突变，引起肿瘤对放疗的抗拒，导致放疗效果差。抗EGFR治疗具有肿瘤放疗增敏作用，目前针对EGFR的分子靶向研究主要有人工合成的单克隆抗体、小分子酪氨酸激酶抑制剂、RNA干扰（RNAi）下调受体表达。

Epidermal growth factor receptor （EGFR） express highly or mutant in esophageal cancer, which causing tumor resistance to radiotherapy and leading to poor radiotherapeutic effects. Treatment with anti- EGFR can get radiosensitization. There are three main types of molecular targeted research for EGFR： synthetic monoclonal antibody, small molecule tyrosine kinase inhibitors, and other strategies modulating EGFR biosynthesis based on RNA interference.