高迁移率蛋白B1与胃癌

HMGB1 and gastric cancer

高迁移率蛋白B1（HMGB1）是一种非组核蛋白，正常情况下，作为细胞核内染色质的组分之一，调节基因的转录、重组、修复等生命活动。在胞外，HMGB1参与细胞的增殖、分化、迁移及神经轴突的生长。研究发现HMGB1与多种肿瘤如肺癌、结肠癌、胰腺癌等的发生发展、浸润转移等生物学行为关系密切。关于HMGB1与胃癌相关性的研究对于胃癌的早期诊断与治疗价值很大。

High mobility group box-1 （HMGB1） is a nonhistone nuclear protein. Normally, as one component of the chromatin, HMGB1 regulate life activities such as genetic transcription, recombination and gene repair. HMGB1 can be realeased to the outside of the cell, which can be bound up with cells multiplication, differentiation, migration and the growth of nerve axon. Studies show that HMGB1 is correlated with tumor occurrence, development, invasion and metastasis, such as lung cancer, colorectal cancer, pancreatic cancer and so on. The studies about the relativity between HMGB1 and gastric cancer play an important role in the diagnosis and treatment of gastric cancers.