摘要
目的探讨口服硝苯地平控释片治疗老年人轻,中度原发性高血压临床疗效。方法采用自身治疗前后对照设计,比较治疗前后收缩压、舒张压和血压变异性;采用健康调查简易量表(the medical outcomes study short form health survey,SF-36)、老年抑郁量表(GeriatricDepression Scale,GDS)评价治疗前后患者生活质量和抑郁情况。结果 11 7例轻、中度原发性高血压老年患者总有效率为84.38%,77.36%。轻、中度老年患者治疗后收缩压和舒张压低于治疗前(P<0.01,P<0.01),治疗后24 h收缩压、舒张压变异性低于治疗前(P<0.01,P<0.01)。轻、中度老年患者治疗后SF-36量表生理功能(physical functioning,PF)、身体疼痛(bodily pain,BP)、总体健康(general health,GH)、活力(vitality,VT)、情感职能(role-emotional,RE)、精神健康(mental health,MH)维度得分高于治疗前(P=0.03,P=0.01,P<0.01,P<0.01,P=0.04,P<0.01;P<0.01,P<0.01,P<0.01,P<0.01.P=0.01,P<0.01)。轻、中度老年治疗后GDS量表得分低于治疗前(P<0.01,P=0.02)。观察期内共有6例患者出现不良反应。结论硝苯地平控释片治疗老年人轻、中度原发性高血压具有较好的降压效果,提示可能有提高生活质量,缓解抑郁症状的临床作用。
Objective To explore the clinical effect of Nifedipine controlled release tablets on geriatric patients with mild or moderate essential hypertension.
Methods Systolic/diastolic blood pressures, and blood pressures variability were compared before and after treatment by self-control design; the quality of life and depression of geriatric patients were evaluated before and after medication using the Medical Outcomes Study Short Form Health Survey(SF-36) and Geriatric Depression Scale(GDS).
Results The total effective rates of the mild and moderate essential hypertension geriatric patients were 84.38% and 77.36%. The systolic and diastolic blood pressure of geriatric patients with mild or moderate essential hypertension after treatment were lower than the systolic and diastolic blood pressure before treatment(P〈0.01, P〈0.01), and the 24h systolic and diastolicblood pressure variability after treatment were lower than before the treatment(P〈0.01, P〈0.01). The scores of physical functioning(PF), bodily pain(BP), general health(GI-I), vitality(VT), role- emotional(RE), mental health(MH) of geriatric patients after 8 weeks treatment were higher than before the treatment(P=-0.03, P=-0.01, P〈0.01, P〈0.01, P=0.04, P〈0.01, P〈0.01, P〈0.01, P〈0.01, P〈0.01, P=0.01, P〈0.01). The scores of GDS were lower than before the treatment (P〈0.01, P=0.02). Six cases of essential hypertensive patients had adverse reactions in observation period.
Conclusions The Nifedipine controlled release tablets on geriatric patients with mild or moderate essential hypertension have a good clinical effect of lowering blood pressure. This study indicatesthe Nifedipine controlled release tablets may have a clinical effect of improving quality of life, and relieving the symptoms of depression.
出处
《中国卒中杂志》
2012年第3期172-177,共6页
Chinese Journal of Stroke