内分泌干扰物与糖代谢异常和肥胖

Endocrine disrupting chemicals,obesity and abnormal glucose metabolism

内分泌干扰物（EDCs）是指影响人体生殖发育和内环境稳态相关激素的合成、分泌、转运、代谢、结合或清除过程的外生物质。长期暴露于EDCs能引起糖耐量异常甚至糖尿病，其可能机制包括：影响葡萄糖转运蛋白（GLUT）4mRNA与核因子（NF）KBmRNA比值、促进雌二醇受体a异常及高胰岛素血症的发生。孕期暴露于EDCs会增加子代成年后肥胖的风险，这种影响可能存在性别差异，其潜在机制是EDCs影响脂代谢过程或脂肪细胞的增殖、分化。

Endocrine disrupting chemicals （EDCs） are defined as exogenous agents that may interfere with synthesis, secretion, transport, metabolism, binding action, or elimination of natural blood-borne hormones that are present in the body and are responsible for homeostasis, reproduction, and developmental process. Long-term exposure to EDCs can cause impaired glucose tolerance or diabetes. The possible mechanisms include：influencing the ratio between GLUT4 mRNA and NFKB mRNA, promoting abnormal estrogen receptor ot and hyperinsulinemia. Exposure to EDCs during pregnancy may increase the risk of offspring＇s obesity when they grow up, this effect may exist gender differences, the potential mechanism is that EDCs affect lipid metabolism or adipocytes proliferation and differentiation