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调节性T细胞在1型糖尿病和胰岛移植中的作用

Effects of regulatory T cells in type 1 diabetes and islet transplantation
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摘要 调节性T细胞是一种免疫抑制性细胞，在维持免疫耐受中起重要作用。研究相继发现了多种调节性T细胞的表面标记和调节性T细胞的作用机制。调节性T细胞的数量和（或）功能缺陷与1型糖尿病的发生、发展密切相关。输注调节性T细胞可以预防和治疗1型糖尿病，延长移植胰岛的存活时间和改善移植物功能。目前，关于调节性T细胞治疗的临床试验研究已经开展，如果后续实验能证实调节性T细胞体内输注治疗的安全性及有效性，调节性T细胞免疫治疗将成为治疗1型糖尿病和预防胰岛移植后免疫排斥的有效方法。 Regulatory T cells （Tregs） are immune suppressor cells,play a key role in maintaining immune tolerance. Studies have found a variety of surface markers and the mechanisms of action of Tregs. The number and （or） functional defect of Tregs is closely related to the occurrence and development of type 1 diabetes （ T1 DM）. Infusion of Tregs can prevent and treat T1 DM, extend the survival time of transplanted islets and improve the function of the graft. At present, clinical trials of Tregs therapy have been carried out. If the safety and feasibility of intravenous infusion of Tregs can be proved, Tregs therapy will be effective for the treatment of T1 DM and the prevention of immune rejection in islet transplantation .
作者 张小娇 张梅
机构地区 南京医科大学第一附属医院内分泌科
出处 《国际内分泌代谢杂志》 北大核心 2012年第2期111-113,123,共4页 International Journal of Endocrinology and Metabolism
基金 基金项目：国家自然科学基金资助项目（81070622） 江苏省自然科学基金资助项目（BK2008444） 南京市科技发展项目（009010684） 江苏六大人才高峰项目（2010-022）
关键词 调节性T细胞 1型糖尿病 胰岛移植 Regulatory T cell Type 1 diabetes mellitus Islet transplantation
分类号 R587.1 [医药卫生—内分泌]
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参考文献18

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二级参考文献10

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国际内分泌代谢杂志
2012年 第2期

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