不孕不育患者支原体感染状况及药物敏感结果分析

Analysis of mycoplasma infection and drug sensitivity test results in infertile patients

目的:探讨不孕不育患者支原体感染状况及对12种抗生素的药敏情况,为临床合理治疗提供参考。方法:对本中心620例不孕不育患者的生殖道分泌物进行支原体培养及体外药敏试验,计算男性及女性患者支原体感染总阳性率、解脲支原体(Uu)及人型支原体(Mh)阳性率,采用卡方检验进行统计学分析。结果:支原体感染总阳性率为18.4%(114/620),男性和女性阳性率分别为13.6%(32/236)、21.4%(82/384)。男性和女性Uu阳性率分别为3.4%(8/236)、16.7%(64/384);Mh阳性率分别为6.8%(16/236)、2.1%(8/384),Uu和Mh合并感染阳性率分别为3.4%(8/236)、2.6%(10/384)。女性患者与男性患者支原体感染阳性率、Uu感染率、Mh感染率以及女性患者的Uu与Mh感染率间差异有统计学意义(P均<0.05)。Uu感染对美满霉素的敏感性最高(100.0%),对环丙沙星的耐药性最强(41.6%);Mh感染对美满霉素的敏感性最高(100.0%),对红霉素、环酯红霉素和克拉霉素的耐药性均达到50.0%;Uu和Mh混合感染对美满霉素的敏感性最高(77.8%),对12种抗生素均有不同程度的耐药性,其中对红霉素的耐药性最强(77.8%)。结论:男性和女性患者支原体感染状况不同,治疗时建议根据药敏结果合理用药。

Objective：To explore the status of mycoplasma infection in infertile patients and its sensitivity to twelve antibiotics to provide a basis for the clinical rational use of drugs.Methods：Genital-tract secretions of 620 infertile patients were taken for mycoplasma culture and antibiotics sensitivity test.The positive rates of mycoplasma,ureaplasma urealyticum（Uu） and mycoplasma hominis（Mh） were calculated,and Chi-square test was used for statistical analysis.Results：The positive rate of mycoplasma infection in infertile patients was 18.4%（114/620）,and those of the female and male groups were 21.4%（82/384） and 13.6%（32/236）,respectively.The positive rate of Uu infection in the female group was 16.7%（64/384） and that in the male group was 3.4%（8/236）.The positive rate of Mh infection in the female group was 2.1%（8/384） and that in the male group was 6.8%（16/236）.The positive rate of Uu and Mh co-infection in the female group was 2.6%（10/384） and that in the male group was 3.4%（8/236）.There were significant differences in positive rates of mycoplasma,Uu and Mh infections between the female and male groups（P all 0.05）.And there was significant difference between the Uu and Mh infection in the female group（P〈0.05）.Drug sensitivity test results showed that Uu infection sensitive to Mincycline was up to 100.0%（72/72） and resistant to ciprofloxacin was up to 41.6%（30/72）;Mh infection sensitive to Mincycline was up to 100.0%（24/24） and resistant to erythromycin,erythromycin ring ester and clarithromycin reached 50%.The Uu and Mh co-infection sensitive to Mincycline was up to 77.8%（14/18） and had different levels of resistance to twelve kinds of antibiotics,and the resistance to erythromycin was up to 77.8%.Conclusion：Mycoplasma infection is high in infertile patients,but shows different characteristics in male and female patients.Mycoplasma infection should be treated according to the drug sensitivity test results.