肺灌洗排尘病因治疗的资料分析和实验研究

Data analysis and experimental study on pathogenic therapy or lung lavage for dust removal

目的针对支气管肺泡灌洗术（ＢＡＬ）治疗尘肺存在议点，探讨 ＢＡＬ治疗尘肺的可能性。方法对 ＢＡＬ治疗尘肺理论依据、肺间质排尘以及影响排尘的主要因素，进行了资料分析和实验研究。结果尘肺发生发展的剂量反应和剂量效应关系，为ＢＡＬ治疗尘肺奠定了理论基础；肺间质封闭技术建立及其应用，证实了肺间质内沉积尘和ＰＡＭ可随ＢＡＬＦ排出体外；尘肺病变程度和染尘后持续时间是影响排尘量的主要因素；模拟ＢＡＬ减尘实验的效果，加深了对尘肺 ＢＡＬ治疗的正确认识。结论ＢＡＬ拟用于早期和急性尘肺的治疗。

Objective Regarding the disagreement on BAL therapy of pneumoconiosis, the main objective is to explore the possibility of BAL therapy of pneumoconiosis. Methods Systematic data analysis and experimental study on academic evidence of BAL therapy of pneumoconiosis, and main factors affecting pulmonary interstitial dust removal. Results The dose-dependent manner in occur rence and development of pneumoconiosis would provide the academic basis for lung lavage; the establishment of pulmonary interstitial blockade and its application verified that the possibility of dusts deposition in interstitum and PAM its removal with BALF; the pathologic degree of pneumoconiosis and time after dust exposure would be the critical reasons on amount of dust removal; the of BAL reduc- ing-dusts appeared to deepen the accurate understanding on BAL therapy of pneumoconiosis. Conclusion BAL would be useful in early and acute pneumoconiosis treatment.