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上皮钙粘蛋白介导的细胞粘附功能异常的分子基础 被引量:5

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摘要 上皮钙粘蛋白被认为是肿瘤侵袭抑制因子。是介导同型细胞细胞间粘附的细胞粘附分子。CDH1/catenin复合体或其中一种成分表达下调可使肿瘤细胞发生侵袭转移。常见的分子基础为转录水平的下调、基因突变、启动子超甲基化等。
作者 李晶
出处 《国外医学(生理病理科学与临床分册)》 2000年第1期46-48,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
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参考文献10

  • 1Berx G,Staes K,van Hengel J,et al. Genomics . 1995
  • 2Berx G,Jansen AMC,Nollet F,et al. EMBO Journal . 1995
  • 3Jiang WG. British Journal of Surgery . 1996
  • 4Hiraguri S,Godfrey T,Nakamura H,et al. Cancer Research . 1998
  • 5Graff J,Herman J,Myohanen S,et al. Journal of Biological Chemistry . 1997
  • 6Graff JR,Herman JG,Lapidus RG,et al. Cancer Research . 1995
  • 7Graff JR,Greenberg VE,Herman JG,et al. Cancer Research . 1998
  • 8Yoshiura K,Kanai Y,Ochiai A,et al. Proceedings of the National Academy of Sciences of the United States of America . 1995
  • 9Tokman MG,Porter RA,Williams CL. Cancer Research . 1997
  • 10Jiang WG,Hiscox S,Hallett MB,et al. Cancer Research . 1995

同被引文献40

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  • 2史洪淼,周政,田芸,王玲,宿芳,李娜,郝立宏.上皮钙黏附素与肿瘤转移的研究进展[J].大连医科大学学报,2005,27(4):280-282. 被引量:10
  • 3王红兵,苗慧,张敬川,祖茂衡,蔡晓敏,吴秀英,胡西旦,迪力努,陈春玲.肺癌E-cadherin基因启动子CpG岛甲基化与蛋白表达的关系及其意义[J].中国癌症杂志,2007,17(8):603-606. 被引量:5
  • 4Esteller M. Epigenetic gene silencing in cancer: the DNA hypermethylome[ J ]. Hum Mol Genet, 2007,16 Spec 1 : R50 - R59.
  • 5Esteller M. Epigenetics provides a new generation of oncogenes and tumorsuppressor genes [ J ]. Br J Cancer, 2006, 94 : 179 - 183.
  • 6Zbar AP, Simopoulos C, Karayiannakis AJ. Cadherins : an integral role in inflammatory bowel disease and mucosal restitution [ J ]. J Gastroenterol,2004,39 (5) :413 - 421.
  • 7Chen CL, Liu SS, Ip SM, et al. E - cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours[ J ]. Eur J Cancer,2003,39 (4) :517 - 523.
  • 8Furuta K, Yoshioka S, Okabe S, et al. Expressions of two adenomatous polyposis coli and E - cadherin proteins on hu- man colorectal cancers [ J ]. Virchows Arch, 2003,442 ( 3 ) : 266 - 270.
  • 9Saito K, Kawakami K, Matsumoto I, et al. Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non - small cell lung cancer [J]. Clin Cancer Res,2010,16(8) :2418 -2426.
  • 10Chen X F, Zhang H T, Qi Q Y, et al. Expression of E-cadherin and nm23 is associated with the elinicopathological factors of hu man non-small cell lung cancer in China[J]. Lung Cance, 2005, 48(1) :69-76.

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