食管癌高发区正常人群食管组织与头发微量元素的分布

Distribution of Trace Element in the Esophageal Tissues and Hair of Normal Population in High Risk Area of Esophageal Carcinoma

目的 探讨食管癌高发区正常人群食管组织与头发中微量元素的变化规律。方法 应用X射线能谱仪扫描电镜及原子吸收分光光度法观测食管癌高发区 2 2 9例不同年龄正常人食管组织与头发中微量元素含量分布。结果 ①食管组织中锌、硒、钼含量随年龄增长逐渐减少 ,铜、钙、镍及铜锌比值随年龄增长而增高 ;②头发中钙的变化与食管组织内变化趋势相反 ,硒的变化无显著差异。结论 在监测食管癌及癌前病变动态变化时 ,应将食管组织、血清及头发检测结果综合在一起 ,整体考虑其变化趋势 ,才能为临床防治食管癌及癌前病变提供准确、可靠的理论依据。

Objective To observe change regularity of trace element in the esophagus and hair of various age groups in high risk area of esophageal carcimona.Methods Trace element quantities in 229 normal esophageal tissue and hair samples of various age groups were determined by x rag energy dispersive spectrometer scanning electron microscope and atomic obsorption spectrophotometry in the esophagus.Results ① Zinc、selenium and molybdenum in the esophagus were decreased and copper、calcium、nickel and Cu/Zn rate were increaesd with age growing gradually,② calcium alteration in the hair was different from that in the tissue,change of selenium in hair was not obvious.Conclusion During surveillance esophageal cancer and precancerous lesion change,it should be thought about variety tendency to determine result of tissue、serum and hair entirely,Accurate theory dependence was provided to clinic prophycactico therapactic of esophageal cancer and precancerous lesion.