降压药物服药时间的研讨

Study on the Administration time of Hypotensors

为了解决传统每日３ 次服药时降压效果不稳定的弊端，随机将３３ 例高血压患者分为常药降压片；双氢克尿噻加尼群地平；心痛定加卡托普利３ 个组。各组均先后按每日３ 次，即８ ００、１２ ００ 、１６ ００ 及６ ００ 、１４００ 、２２００ 间隔８ ｈ 的两种时间服药。测量并记录每位患者６００、８ ００ 、１０００、１６ ００、１８ ００ 、２０ ００ 血压，以观察其降压效果。结果经方差分析，各时点的Ｆ值均＜ ５－３９，３ 组药物的疗效无显著性差异，表明疗效与药物品种无关；相同药物，同一患者，同一时点，不同时间间隔服药的收缩压、舒张压的血压值有显著性差异（ｔ＞ ３－１６９ ，Ｐ＜ ０－０１） 。提示：８ ｈ 间隔服药，可充分利用药效学原理，改变药物效应，保持药效平稳，提高治疗效果。

In order to avoid the disadvantages of unstable effects of hypotensors 3 times per day, 33 patients with hypertension were randomly divided into three groups: ordinary hypotensor group, group of dihydrochlorothiazide plus, group of nifepine plus. All patients took hypotensors 3 times per day in two administrations: 800, 1200, 1600 ; 600, 1400, 2200 in an interval of 8 h. The blood pressure of each patient was monitored in an interval of 2 h, that was 600, 800, 1000, 1600, 1800, 20:00 to observe the effects of the hypotensors. The analysis of variance showed that the F values at each time point were <5 39 with no significant difference among the three groups. It was found that the therapeutic effects were not related to the medicines. The blood pressure difference of systolic pressure and diastolic pressure at the same hypotensor, the same patient, the same time point and different time intervals for administration had a significant difference ( t ≥3 169, P <0 01). It was suggested that the administration of 8 h interval could pick up the hypotensor effects, maintain the stable hypotensor response and increase the therapeutic effects.