摘要
目的:探讨川芎嗪对大鼠脑缺血再灌注损伤的保护作用及其机制。方法:采用大鼠双侧颈总动脉闭塞的不完全性脑缺血再灌注模型,测定血浆中一氧化氮(NO)及中分子物质(MMS)总量和脑组织中丙二醛(MDA)含量变化。结果:川芎嗪(33.3mg/kg,ip)显著增加缺血大鼠血浆中NO含量,降低MMS总量和组织中MDA的含量,以及降低血比粘度。结论:川芎嗪对大鼠脑缺血再灌注损伤具有保护作用,其机制与抗脂质过氧化、增加NO含量和降低MMS总量作用有关。
Objective:the study is to observed the protective effects of ligustrazine on acute brain ischemia reperfusion injury in rats.Method:the content of plasma nitric oxide (NO) and middle molecule substance(MMS) and the content of brain tissue malondialdehyde(MDA) were detected using the models of incomplete brain ischemia reperfuing in rates by closing bilateral common carotid arteries.Result:ligustrazine could significantly increase nitric oxide content,reduced middle molecule sudstance and malondialdehyd content and viscosity of blood injury in rats.Conclusion:the protective effects of ligustrazine on cerebral ischemia injury may be related to its antilipid peroxidation and increased NO content and also decreased MMS level.
出处
《安徽中医学院学报》
CAS
2000年第1期44-45,共2页
Journal of Anhui Traditional Chinese Medical College
关键词
川芎嗪
脑缺血
再灌注损伤
保护作用
Ligustrazine
Brain ischemin
Lipid peroxidation
Middle molecule substance
Nitric oxide
Malondialdehyde
