老年胃癌组织血管内皮生长因子的表达和微血管密度与预后的关系研究

Expression of vascular endothelial growth factor and microvessel density in elderly gastric cancer and the relationship with prognostic

目的探讨老年胃癌组织血管内皮生长因子(VEGF)的表达和微血管密度(MVD)与预后的关系。方法选择68例老年胃癌患者作为研究对象,应用免疫组织化学方法检测胃癌组织及癌旁组织VEGF及MVD,对VEGF、MVD与患者预后的关系进行统计学分析。结果胃癌组织与癌旁组织VEGF阳性率分别为60.3%及8.8%,胃癌组织高于癌旁组织(P<0.01);VEGF阳性及MVD升高患者3 a生存率及5 a生存率低于VEGF阴性及MVD正常者(P<0.01);VEGF及MVD与患者临床分期、淋巴结转移及远行转移有关(P<0.01)。结论 VEGF表达与血管生成和肿瘤进展密切相关,可作为预测老年胃癌患者预后的重要因素。

Objective To explore the expression of vascular endothelial growth factor（VEGF） and microvessel density（MVD） in elderly gastric cancer and the relationship between VEGF,MVD and prognosis. Methods Immunohistochemistry method was performed to detect VEGF and MVD in 68 elderly patients with gastric cancer.The relationship between VEGF,MVD and prognosis were analysed. Results The positive rate of VEGF in gastric cancer tissue and adjacent tissues were 60.3% and 8.8% respectively（P0.01）;the three years survival rate and five years survival rate were lower in patients with positive VEGF and high MVD level than patients with negative VEGF and normal MVD level（P0.01）.Both VEGF expression and MVD were associated with tumour node metastases（TNM） stage,lymph node metastasis and tumor invasion. Conclusion VEGF expression has close relationship with angiogenesis and tumor progress,and it is an important prognostic factors for elderly gastric cancer.