VX2兔肿瘤转移性及炎性增生性淋巴结的动态增强磁共振成像实验研究

Experimental study of VX2 rabbits metastatic and inflammatory adenopathy by using dynamic contrast-enhanced MR imaging

目的评价动态增强磁共振成像在VX2兔肿瘤转移性、炎性增生性淋巴结鉴别诊断中的价值。方法20只健康新西兰大白兔随机分为肿瘤转移性淋巴结组、炎性增生性淋巴结组，每组10只。对两组淋巴结分别进行动态增强磁共振成像。结果9个肿瘤转移性淋巴结及9个炎性增生性淋巴结成功进行动态增强磁共振成像。肿瘤转移性淋巴结组时间信号曲线以速升平台型为主，峰值增强率、峰值时间、最大强化速率分别为284％±125％、（118±47）s和（6．5±2．7）％／s；而炎性增生性淋巴结组时间信号曲线以持续上升型为主，峰值增强率、峰值时间、最大强化速率分别为199％±109％、（143±40）s和（3．6±1．5）％／s，二者比较差异有统计学意义（P〈0．05）。结论动态增强磁共振成像可准确反映VX2兔肿瘤转移性及炎性增生性淋巴结的血流动力学特征并对其进行鉴别诊断。

Objective To study the dynamic contrast-enhanced magnetic resonance imaging （DCE- MRI ） features of VX2 rabbits carcinoma metastatic and inflammatory lymph nodes. Methods Twenty healthy adult New Zealand white rabbits were divided into metastatic lymph node group and inflammatory lymph node group randomly. There were ten rabbits in each group. All 20 rabbits underwent DCE-MRI. Peak enhancement, time to peak, maximum slope and signal intensity versus time curves were generated from each node individually. Results DCE-MRI were obtained for nine cases of metastatic lymph nodes and nine cases of inflammatory lymph nodes. The signal intensity versus time curves of metastatic lymph nodes were appeared as rapid ascending and plateaning, and peak enhancement, time to peak, maximum slope of metastatic lymph nodes group were 284% ± 125% , （118 ±47） s and （6. 5± 2.7） %/s, respectively. The signal intensity versus time curves of inflammatory lymph nodes were appeared as insisting ascending, and peak enhancement, time to peak, maximum slope of inflammatory lymph nodes group were 199% _＋ 109% , （143 ± 40 ） s and （3.6 ± 1.5 ） %/s, respectively. There was significantly higher peak enhancement, shorter time to peak and higher maximum slope in the metastatic lymph nodes group compared with the inflammatory lymph nodes group （P 〈 0. 05 ）. Conclusions DCE-MRI can accurately reflect the hemodynamie characteristics of VX2 rabbits neoplasm metastatic lymph nodes and inflammatory lymph nodes, and can differentiate VX2 rabbits neoplasm metastatic lymph nodes from inflammatory lymph nodes.