喜炎平注射液治疗慢性阻塞性肺疾病急性加重的疗效研究

Curative effect of Xiyanping jnjection in acute exacerbations of chronic obstructive pulmonary disease

目的观察喜炎平注射液治疗慢性阻塞性肺疾病急性加重(AECOPD)的疗效。方法将60例AECOPD患者按轻、重入选标准分为两组:将轻症患者随机分为常规对照组及单用喜炎平注射液治疗组,重症患者随机分为常规对照组及常规治疗+喜炎平注射液治疗组。4组患者分别治疗2周后,观察患者的一般状态,包括体温、呼吸、脉搏,饮食,观察患者咳痰量的变化情况,听诊肺部啰音吸收情况。结果轻症组喜炎平注射液治疗组与常规对照组疗效比较差异无统计学意义(P>0.05),而重症组常规治疗+喜炎平注射液组比单独常规对照组疗效明显,差异有统计学意义(P<0.05)。结论在轻症AE-COPD患者中,单独应用喜炎平注射液能取得和常规对照同样的效果;而在重症患者中,加用喜炎平治疗组可使症状明显好转,喜炎平注射液在AECOPD治疗中的疗效确切。

Objective To observe curative effect of Xiyanping injection in the treatment of a- cute exacerbations of chronic obstructive pulmonary disease （AECOPD）. Methods Sixty pa- tients with AECOPD were divided into two groups according to the severity： mild patients were then randomly divided into conventional treatment group and Xiyanping injection group, while severe patients were then randomly divided into conventional treatment group and the routine treatment ＋ Xiyanping injection group. All the patients were treated for 2 weeks, then general conditions were observed, including body temperature, breathing, pulse, and diet. The chan- ges of sputum volume and lung auscultation sound among groups were compared. Results The therapeutic effect on patients with Xiyanping injection alone in mild group had no significant difference compared with those with conventional treatment（P 〉 0.05 ）, while in severe group, the difference of efficacy between conventional treatment ＋ Xiyanping injection group and the routine treatment group alone was statistically significant （P 〈 0.05）. Conclusion Xiyanpinginjection improves symptoms of severe AECOPD patients significantly, and it has a definite effect in the treatment of AECOPD.